Simon-Oppermann C, Eriksson S, Simon E, Gray D A
Max-Planck-Institut für Physiologische, W.G. Kerckhoff-Institut, Bad Nauheim, F.R.G.
Brain Res. 1987 Oct 20;424(1):163-8. doi: 10.1016/0006-8993(87)91206-6.
Dogs were chronically implanted with two devices for cerebrospinal fluid (CSF) sampling from (a) the anterior part of the 3rd ventricle and (b) the cisterna magna. In conscious dogs arginine vasopressin (AVP) concentration of CSF samples collected at different occasions were 2-3 times higher in the CSF of the 3rd ventricle as compared to the AVP concentration of the cisterna magna. Inhalation anesthesia stimulated AVP release into the CSF at both sites by a factor of about 2, the gradient between 3rd ventricle and cisterna magna CSF of 2-3 remained for AVP in simultaneously collected samples. In contrast, angiotensin II-like immunoreactivity of CSF was not significantly different at both sites, neither in the conscious dogs nor during anesthesia. It is concluded that the main amount of AVP enters the CSF at the 3rd ventricular level.
给狗长期植入两种用于采集脑脊液（CSF）的装置，分别用于从（a）第三脑室前部和（b）枕大池采集脑脊液。清醒的狗在不同时间采集的脑脊液样本中，第三脑室脑脊液中精氨酸加压素（AVP）的浓度比枕大池脑脊液中AVP的浓度高2至3倍。吸入麻醉使两个部位的脑脊液中AVP释放量增加约2倍，同时采集的样本中，第三脑室和枕大池脑脊液中AVP的2至3倍的梯度仍然存在。相比之下，无论是清醒的狗还是麻醉期间，两个部位脑脊液中血管紧张素II样免疫反应性均无显著差异。得出的结论是，大部分AVP在第三脑室水平进入脑脊液。
