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乙酰胆碱可降低用单电极电压钳技术在猫运动皮层神经元体内测量的外向净电流。

Acetylcholine reduces net outward currents measured in vivo with single electrode voltage clamp techniques in neurons of the motor cortex of cats.

作者信息

Woody C D, Gruen E

机构信息

Department of Anatomy, UCLA Medical Center 90024.

出版信息

Brain Res. 1987 Oct 20;424(1):193-8. doi: 10.1016/0006-8993(87)91210-8.

DOI:10.1016/0006-8993(87)91210-8
PMID:3690299
Abstract

Effects of acetylcholine (ACh) on membrane currents of cells of the motor cortex were measured directly, in vivo, in awake cats using single electrode voltage clamp (SEVC) techniques. Extracellular applications (90-95 nA) of 2 M ACh for periods of 30 s or less produced significant decreases in net outward currents elicited by depolarizing commands whereas applications of saline did not. Reductions of net outward currents were also obtained after intracellular pressure injections of cyclic guanosine monophosphate (GMP)-dependent protein kinase (cGPK) mixed with 10 microM cyclic GMP.

摘要

利用单电极电压钳（SEVC）技术，在清醒猫的活体状态下直接测量了乙酰胆碱（ACh）对运动皮质细胞的膜电流的影响。在细胞外施加2 M ACh（90 - 95 nA），持续30秒或更短时间，会使去极化指令引发的净外向电流显著降低，而施加生理盐水则不会。在细胞内压力注射与10 microM环鸟苷单磷酸（cGMP）混合的环鸟苷单磷酸（GMP）依赖性蛋白激酶（cGPK）后，也观察到了净外向电流的降低。

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