Holmes G L, Thompson J L
Department of Neurology, Medical College of Georgia, Veteran's Medical Center, Augusta 30912.
Brain Res. 1987 Dec 1;433(2):281-4. doi: 10.1016/0165-3806(87)90032-0.
Bipolar electrodes, stereotaxically implanted in the hippocampus and amygdala of prepubescent rats, were used to deliver 1- or 10-s trains of suprathreshold bipolar stimulations at frequencies of 10 or 60 Hz. The stimuli were administered every 5 min. Rapid kindling was achieved with 10-s but not 1-s stimulation with both 10- and 60-Hz frequencies. Ten-s stimulations with a 60-Hz frequency resulted in more rapid kindling than 10-s stimulations with a 10-Hz frequency. The rate of kindling was similar in the hippocampus and amygdala. In the immature animal rapid kindling can be achieved with electrical stimulations with long duration and short interstimulus intervals.
