Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Nutrients. 2023 Feb 21;15(5):1083. doi: 10.3390/nu15051083.
The prevalence rate of hyperuricemia remains high in Taiwan, at 21.6% in men and 9.57% in women. Both metabolic syndrome (MetS) and hyperuricemia can cause many complications; however, few studies have evaluated the correlation between MetS and hyperuricemia. Therefore, in this observational cohort study, we explored associations between metabolic syndrome (MetS) and its components and new-onset hyperuricemia. Of 27,033 individuals in the Taiwan Biobank who had complete follow-up data, we excluded those with hyperuricemia at baseline ( = 4871), those with gout at baseline ( = 1043), those with no data on baseline uric acid ( = 18), and those with no data on follow-up uric acid ( = 71). The remaining 21,030 participants (mean age 50.8 ± 10.3 years) were enrolled. We found a significant association between new-onset hyperuricemia with MetS and the components of MetS (hypertriglyceridemia, abdominal obesity, low high-density lipoprotein cholesterol, hyperglycemia, and high blood pressure). Furthermore, compared to those without any MetS components, those with one MetS component (OR = 1.816), two MetS components (OR = 2.727), three MetS components (OR = 3.208), four MetS components (OR = 4.256), and five MetS components (OR = 5.282) were significantly associated with new-onset hyperuricemia (all < 0.001). MetS and its five components were associated with new-onset hyperuricemia in the enrolled participants. Further, an increase in the number of MetS components was associated with an increase in the incidence rate of new-onset hyperuricemia.
台湾地区高尿酸血症的患病率仍居高不下，男性为 21.6%，女性为 9.57%。代谢综合征（MetS）和高尿酸血症均可引起多种并发症；然而，很少有研究评估 MetS 与高尿酸血症之间的相关性。因此，在这项观察性队列研究中，我们探讨了代谢综合征（MetS）及其成分与新发高尿酸血症之间的关系。在台湾生物库中，有 27033 名个体有完整的随访数据，我们排除了基线时患有高尿酸血症的个体（=4871）、基线时患有痛风的个体（=1043）、基线时尿酸数据缺失的个体（=18）和随访时尿酸数据缺失的个体（=71）。剩余的 21030 名参与者（平均年龄 50.8±10.3 岁）被纳入研究。我们发现新发高尿酸血症与 MetS 及其成分（高三酰甘油血症、腹型肥胖、低高密度脂蛋白胆固醇血症、高血糖和高血压）之间存在显著相关性。此外，与没有任何 MetS 成分的个体相比，具有一个 MetS 成分（OR=1.816）、两个 MetS 成分（OR=2.727）、三个 MetS 成分（OR=3.208）、四个 MetS 成分（OR=4.256）和五个 MetS 成分（OR=5.282）的个体发生新发高尿酸血症的风险显著升高（均<0.001）。MetS 及其五个成分与纳入研究的个体新发高尿酸血症相关，并且 MetS 成分的数量增加与新发高尿酸血症的发生率增加相关。
