Division of Gastroenterology, Department of Medicine, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Department of Orthopedics, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Nutrients. 2023 Feb 23;15(5):1123. doi: 10.3390/nu15051123.
Fatty liver is known to be associated with extra-hepatic diseases including atherosclerotic cardiovascular disease and extra-hepatic cancers, which affect the prognosis and quality of life of the patients. The inter-organ crosstalk is mediated by metabolic abnormalities such as insulin resistance and visceral adiposity. Recently, metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed as a new definition for fatty liver. MAFLD is characterized by the inclusion criteria of metabolic abnormality. Therefore, MAFLD is expected to identify patients at high risk of extra-hepatic complications. In this review, we focus on the relationships between MAFLD and multi-organ diseases. We also describe the pathogenic mechanisms of the inter-organ crosstalk.
脂肪肝与包括动脉粥样硬化性心血管疾病和肝外癌症在内的肝外疾病有关，这些疾病会影响患者的预后和生活质量。器官间的串扰是由代谢异常介导的，如胰岛素抵抗和内脏肥胖。最近，代谢相关脂肪性肝病（MAFLD）被提出作为脂肪肝的一个新定义。MAFLD 的特点是包括代谢异常的纳入标准。因此，MAFLD 有望识别出有肝外并发症高风险的患者。在这篇综述中，我们重点讨论了 MAFLD 与多器官疾病之间的关系。我们还描述了器官间串扰的发病机制。
