血清 25-羟维生素 D 与美国人群中早发性和晚发性年龄相关性黄斑变性的相关性存在差异。

Serum 25-Hydroxyvitamin D Is Differentially Associated with Early and Late Age-Related Macular Degeneration in the United States Population.

机构信息

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China.

出版信息

Nutrients. 2023 Feb 28;15(5):1216. doi: 10.3390/nu15051216.

DOI:10.3390/nu15051216

PMID:36904215

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10005371/

Abstract

BACKGROUND

Age-related macular degeneration (AMD) has been the leading cause of irreversible blindness in industrialized countries. Emerging data suggest that serum vitamin D levels may be associated with AMD but show mixed results. National-level population data on the relationship between vitamin D and AMD severities are still lacking.

METHODS

We used data from the National Health and Nutrition Examination Survey (NHANES) 2005 to 2008. Retinal photographs were taken and graded for AMD stage. The odds ratio (OR) of AMD and its subtype was calculated after adjusting for confounding factors. Restricted cubic spline (RCS) analyses were used to explore potential non-linear relations.

RESULTS

A total of 5041 participants with a mean age of 59.6 years were included. After adjusting for covariates, participants with higher level of serum 25-hydroxyvitamin D [25(OH)D] had significantly greater odds of early AMD (OR, 1.65; 95% CI, 1.08-2.51) and decreased risk of late AMD (OR, 0.29; 95% CI, 0.09-0.88). When stratified by age, a positive association between the level of serum 25(OH)D and early AMD was present in the <60 years group (OR, 2.79; 95% CI, 1.08-7.29), whereas a negative relation between the level of serum 25(OH)D and late AMD was detected in the ≥60 years group (OR, 0.24; 95% CI, 0.08-0.76).

CONCLUSIONS

A higher level of serum 25(OH)D was related to increased risk of early AMD in those <60 years and decreased risk of late AMD in those ≥60 years.

摘要

背景

年龄相关性黄斑变性（AMD）是工业化国家致盲的主要原因。新出现的数据表明，血清维生素 D 水平可能与 AMD 有关，但结果不一。关于维生素 D 与 AMD 严重程度之间关系的国家级人群数据仍缺乏。

方法

我们使用了 2005 年至 2008 年全国健康与营养调查（NHANES）的数据。对视网膜照片进行拍摄和分级以确定 AMD 分期。在调整混杂因素后，计算 AMD 及其亚型的比值比（OR）。采用限制三次样条（RCS）分析来探索潜在的非线性关系。

结果

共纳入 5041 名平均年龄为 59.6 岁的参与者。在调整了协变量后，血清 25-羟维生素 D [25（OH）D] 水平较高的患者发生早期 AMD 的几率显著增加（OR，1.65；95%CI，1.08-2.51），而晚期 AMD 的风险降低（OR，0.29；95%CI，0.09-0.88）。按年龄分层时，血清 25（OH）D 水平与早期 AMD 之间存在正相关，在<60 岁组中（OR，2.79；95%CI，1.08-7.29），而在≥60 岁组中，血清 25（OH）D 水平与晚期 AMD 之间呈负相关（OR，0.24；95%CI，0.08-0.76）。