Department of Food Technology, Federal University of Viçosa, Viçosa 36570-900, MG, Brazil.
Department of Nutrition and Health, Federal University of Viçosa, Viçosa 36570-900, MG, Brazil.
Nutrients. 2023 Mar 2;15(5):1252. doi: 10.3390/nu15051252.
Macauba is a palm tree native to Brazil, which fruits are rich in oil. Macauba pulp oil has high contents of oleic acid, carotenoids, and tocopherol, but its effect on health is unknown. We hypothesized that macauba pulp oil would prevent adipogenesis and inflammation in mice. Thus, the purpose of this study was to evaluate the effects of macauba pulp oil on the metabolic changes in C57Bl/6 mice fed a high-fat diet. Three experimental groups were used ( = 10): control diet (CD), high-fat diet (HFD), and high-fat diet with macauba pulp oil (HFM). The HFM reduced malondialdehyde and increased SOD activity and antioxidant capacity (TAC), showing high positive correlations between total tocopherol, oleic acid, and carotenoid intakes and SOD activity (r = 0.9642, r = 0.8770, and r = 0.8585, respectively). The animals fed the HFM had lower levels of PPAR-γ and NF-κB, which were negatively correlated with oleic acid intake (r = -0.7809 and r = -0.7831, respectively). Moreover, the consumption of macauba pulp oil reduced inflammatory infiltrate, adipocyte number and length, (mRNA) , and (mRNA) in the adipose tissue, and it increased (mRNA) . Therefore, macauba pulp oil prevents oxidative stress, inflammation, and adipogenesis and increases antioxidant capacity; these results highlight its potential against metabolic changes induced by an HFD.
巴西本土的一种棕榈树——巴西棕榈的果实富含油脂。巴西棕榈果肉油含有丰富的油酸、类胡萝卜素和生育酚，但对其健康功效尚不明确。我们假设巴西棕榈果肉油可预防小鼠脂肪生成和炎症。因此，本研究旨在评估巴西棕榈果肉油对高脂肪饮食喂养的 C57Bl/6 小鼠代谢变化的影响。共使用了 3 个实验组（n=10）：基础饮食组（CD）、高脂肪饮食组（HFD）和高脂肪饮食加巴西棕榈果肉油组（HFM）。HFM 降低了丙二醛含量，增加了 SOD 活性和抗氧化能力（TAC），总生育酚、油酸和类胡萝卜素的摄入量与 SOD 活性之间呈高度正相关（r=0.9642、r=0.8770 和 r=0.8585）。HFM 喂养的动物的 PPAR-γ 和 NF-κB 水平较低，与油酸的摄入量呈负相关（r=-0.7809 和 r=-0.7831）。此外，巴西棕榈果肉油的摄入减少了脂肪组织中的炎症浸润、脂肪细胞数量和长度以及（mRNA）和（mRNA），并增加了（mRNA）。因此，巴西棕榈果肉油可预防氧化应激、炎症和脂肪生成，并增加抗氧化能力；这些结果强调了其对 HFD 诱导的代谢变化的潜在作用。
