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微注塑成型工艺参数对聚乳酸微针阵列产品复制质量的影响研究

Study on the Influence of Microinjection Molding Processing Parameters on Replication Quality of Polylactic Acid Microneedle Array Product.

作者信息

Yu Wenqian, Gu Junfeng, Li Zheng, Ruan Shilun, Chen Biaosong, Shen Changyu, Lee Ly James, Wang Xinyu

机构信息

Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, China.

Ningbo Research Institute of Dalian University of Technology, Ningbo 315016, China.

出版信息

Polymers (Basel). 2023 Feb 27;15(5):1199. doi: 10.3390/polym15051199.

DOI:10.3390/polym15051199
PMID:36904441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10007380/
Abstract

Biodegradable microneedles with a drug delivery channel have enormous potential for consumers, including use in chronic disease, vaccines, and beauty applications, due to being painless and scarless. This study designed a microinjection mold to fabricate a biodegradable polylactic acid (PLA) in-plane microneedle array product. In order to ensure that the microcavities could be well filled before production, the influences of the processing parameters on the filling fraction were investigated. The results indicated that the PLA microneedle can be filled under fast filling, higher melt temperature, higher mold temperature, and higher packing pressure, although the dimensions of the microcavities were much smaller than the base portion. We also observed that the side microcavities filled better than the central ones under certain processing parameters. However, this does not mean that the side microcavities filled better than the central ones. The central microcavity was filled when the side microcavities were not, under certain conditions in this study. The final filling fraction was determined by the combination of all parameters, according to the analysis of a 16 orthogonal latin hypercube sampling analysis. This analysis also showed the distribution in any two-parameter space as to whether the product was filled entirely or not. Finally, the microneedle array product was fabricated according to the investigation in this study.

摘要

具有药物输送通道的可生物降解微针由于无痛且无疤痕，在包括慢性病、疫苗和美容应用在内的消费领域具有巨大潜力。本研究设计了一种微注射模具，用于制造可生物降解的聚乳酸（PLA）平面微针阵列产品。为了确保在生产前微腔能够被良好填充，研究了加工参数对填充率的影响。结果表明，尽管微腔尺寸远小于基部，但在快速填充、较高熔体温度、较高模具温度和较高保压压力下，PLA微针能够被填充。我们还观察到，在某些加工参数下，侧面微腔的填充效果优于中央微腔。然而，这并不意味着侧面微腔总是比中央微腔填充得更好。在本研究的某些条件下，当侧面微腔未被填充时，中央微腔却被填充了。根据16正交拉丁超立方抽样分析，最终填充率由所有参数的组合决定。该分析还显示了在任何两参数空间中产品是否完全填充的分布情况。最后，根据本研究的结果制造出了微针阵列产品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/3d5214822659/polymers-15-01199-g015.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/ab7a1df4dd7e/polymers-15-01199-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/9e72de970328/polymers-15-01199-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/1715d551f8ca/polymers-15-01199-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/7a0fc06cf8be/polymers-15-01199-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/08d1b4377d2f/polymers-15-01199-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/71f47017f951/polymers-15-01199-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/280faff74e76/polymers-15-01199-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/86124a405c6f/polymers-15-01199-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/3d5214822659/polymers-15-01199-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/f9bf04287286/polymers-15-01199-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/a579e30cf6a1/polymers-15-01199-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/53c96428c8d9/polymers-15-01199-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/4c47202c5dc0/polymers-15-01199-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/12b9e903bb60/polymers-15-01199-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/ca86f99fdc17/polymers-15-01199-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/ab7a1df4dd7e/polymers-15-01199-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/9e72de970328/polymers-15-01199-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/1715d551f8ca/polymers-15-01199-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/7a0fc06cf8be/polymers-15-01199-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/08d1b4377d2f/polymers-15-01199-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/71f47017f951/polymers-15-01199-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/280faff74e76/polymers-15-01199-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/86124a405c6f/polymers-15-01199-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e517/10007380/3d5214822659/polymers-15-01199-g015.jpg

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含二氢愈创木酸的多功能微针贴片，可用于潜在的伤口敷料。
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