School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Sensors (Basel). 2023 Feb 22;23(5):2438. doi: 10.3390/s23052438.
In the process of manufacture and transportation, vials are prone to breakage and cracks. Oxygen (O) in the air entering vials can lead to the deterioration of medicine and a reduction in pesticide effects, threatening the life of patients. Therefore, accurate measurement of the headspace O concentration for vials is crucial to ensure pharmaceutical quality. In this invited paper, a novel headspace oxygen concentration measurement (HOCM) sensor for vials was developed based on tunable diode laser absorption spectroscopy (TDLAS). First, a long-optical-path multi-pass cell was designed by optimizing the original system. Moreover, vials with different O concentrations (0%, 5%, 10%, 15%, 20%, and 25%) were measured with this optimized system in order to study the relationship between the leakage coefficient and O concentration; the root mean square error of the fitting was 0.13. Moreover, the measurement accuracy indicates that the novel HOCM sensor achieved an average percentage error of 1.9%. Sealed vials with different leakage holes (4, 6, 8, and 10 mm) were prepared to investigate the variation in the headspace O concentration with time. The results show that the novel HOCM sensor is non-invasive and has a fast response and high accuracy, with prospects in applications for online quality supervision and management of production lines.
在制造和运输过程中，小瓶容易破裂和出现裂缝。进入小瓶的空气中的氧气（O）会导致药物变质和降低农药效果，威胁患者的生命。因此，准确测量小瓶的顶空 O 浓度对于确保药物质量至关重要。在这篇特邀论文中，开发了一种基于可调谐二极管激光吸收光谱（TDLAS）的新型小瓶顶空氧气浓度测量（HOCM）传感器。首先，通过优化原始系统设计了一个长光程多通池。此外，使用该优化系统测量了具有不同 O 浓度（0%、5%、10%、15%、20%和 25%）的小瓶，以研究泄漏系数与 O 浓度之间的关系；拟合的均方根误差为 0.13。此外，测量精度表明，新型 HOCM 传感器的平均百分比误差为 1.9%。制备了具有不同泄漏孔（4、6、8 和 10mm）的密封小瓶，以研究顶空 O 浓度随时间的变化。结果表明，新型 HOCM 传感器是非侵入式的，具有快速响应和高精度，有望在线应用于生产线的质量监督和管理。
