Department of Chemical Engineering, College of Engineering, Jazan University, P.O. Box. 706, Jazan, Saudi Arabia.
School of Chemical Engineering, Universiti Sains Malaysia, Engineering Campus, Nibong Tebal, Penang, Malaysia.
Luminescence. 2023 Jul;38(7):1064-1086. doi: 10.1002/bio.4408. Epub 2022 Dec 3.
The penicillin derivative amoxicillin (AMX) plays an important role in treating various types of infections caused by bacteria. However, excessive use of AMX may have negative health effects. Therefore, it is of utmost importance to detect and quantify the AMX in pharmaceutical drugs, biological fluids, and environmental samples with high sensitivity. Therefore, this review article provides valuable and up-to-date information on nanostructured material-based optical and electrochemical sensors to detect AMX in various biological and chemical samples. The role of using different nanostructured materials on the performance of important optical sensors such as colorimetric sensors, fluorescence sensors, surface-enhanced Raman scattering sensors, chemiluminescence/electroluminescence sensors, optical immunosensors, optical fibre-based sensors, and several important electrochemical sensors based on different electrode types have been discussed. Moreover, nanocomposites, polymer, and MXenes-based electrochemical sensors have also been discussed, in which such materials are being used to further enhance the sensitivity of these sensors. Furthermore, nanocomposite-based photo-electrochemical sensors and the market availability of biosensors including AMX have also been discussed briefly. Finally, the conclusion, challenges, and future perspectives of the above-mentioned sensing techniques for AMX detection are presented.
青霉素衍生物阿莫西林（AMX）在治疗各种细菌引起的感染方面发挥着重要作用。然而，过量使用 AMX 可能会对健康产生负面影响。因此，用高灵敏度检测和定量测定药物、生物体液和环境样品中的 AMX 至关重要。因此，本文综述了基于纳米结构材料的光学和电化学传感器在各种生物和化学样品中检测 AMX 的最新研究进展。讨论了使用不同纳米结构材料对重要光学传感器（如比色传感器、荧光传感器、表面增强拉曼散射传感器、化学发光/电致发光传感器、光免疫传感器、光纤传感器和几种基于不同电极类型的重要电化学传感器）性能的影响。此外，还讨论了基于纳米复合材料、聚合物和 MXenes 的电化学传感器，其中这些材料被用于进一步提高这些传感器的灵敏度。此外，还简要讨论了基于纳米复合材料的光电化学传感器和包括 AMX 在内的生物传感器的市场可用性。最后，提出了上述 AMX 检测传感技术的结论、挑战和未来展望。
