神经外科应用的磁热疗
Neurosurgical Applications of Magnetic Hyperthermia Therapy.
机构信息
Department of Neurological Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Suite F-158, Pittsburgh, PA 15213, USA; Brain Tumor Nanotechnology Laboratory, UPMC Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15232, USA.
Department of Neurological Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
出版信息
Neurosurg Clin N Am. 2023 Apr;34(2):269-283. doi: 10.1016/j.nec.2022.11.004. Epub 2023 Jan 30.
Abstract
Magnetic hyperthermia therapy (MHT) is a highly localized form of hyperthermia therapy (HT) that has been effective in treating various forms of cancer. Many clinical and preclinical studies have applied MHT to treat aggressive forms of brain cancer and assessed its role as a potential adjuvant to current therapies. Initial results show that MHT has a strong antitumor effect in animal studies and a positive association with overall survival in human glioma patients. Although MHT is a promising therapy with the potential to be incorporated into the future treatment of brain cancer, significant advancement of current MHT technology is required.
摘要
磁热疗（MHT）是一种高度局部化的热疗（HT）形式，已被证明对各种形式的癌症有效。许多临床前和临床研究已经将 MHT 应用于治疗侵袭性脑癌，并评估了其作为当前治疗方法的潜在辅助手段的作用。初步结果表明，MHT 在动物研究中具有很强的抗肿瘤作用，并与人类脑胶质瘤患者的总生存率呈正相关。尽管 MHT 是一种很有前途的治疗方法，有可能被纳入未来的脑癌治疗，但需要对当前的 MHT 技术进行重大改进。
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