Guggenmoos R, Akhtaruzzaman K M, Rosenkaimer F, Gaus W, Bienzle U, Dietrich M
Tropenmed Parasitol. 1978 Dec;29(4):423-6.
In a double-blind study in Cameroon the vermicidal effect of Ciclobendazole, a new Benzimidazole derivative, was evaluated and compared to Mebendazole. Ciclobendazole and Mebendazole were equally effective in the treatment of Ascaris and Hookworm infestations. An increase in the dosis of Ciclobendazole from 600 mg to 1200 mg did not lead to an improvement in the effectiveness. When treating trichuriasis significantly better results were achieved with Mebendazole (p = 0.01). Both drugs were tolerated equally well. Side effects, such as vomiting and diarrhoea, only occurred in a small percentage of cases.
在喀麦隆进行的一项双盲研究中，对新型苯并咪唑衍生物环苯达唑的杀蠕虫效果进行了评估，并与甲苯达唑进行了比较。环苯达唑和甲苯达唑在治疗蛔虫和钩虫感染方面同样有效。将环苯达唑的剂量从600毫克增加到1200毫克并没有提高疗效。在治疗鞭虫病时，甲苯达唑取得了明显更好的效果（p = 0.01）。两种药物的耐受性相当。呕吐和腹泻等副作用仅在一小部分病例中出现。
