Geo-Bio-Environment Engineering and Innovation Laboratory, Molecular Engineering, Biotechnology and Innovation Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Agadir, Morocco.
Physiology and Physiopathology Team, Faculty of Sciences, Genomic of Human Pathologies Research, Mohammed V University, Rabat, Morocco.
Crit Rev Food Sci Nutr. 2024 Jul;64(21):7589-7608. doi: 10.1080/10408398.2023.2187622. Epub 2023 Mar 13.
The field of nutrigenomics studies the interaction between nutrition and genetics, and how certain dietary patterns can impact gene expression and overall health. The Mediterranean diet (MedDiet), characterized by a high intake of fruits, vegetables, whole grains, and healthy fats, has been linked to better cardiovascular health (CVH) outcomes. This review summarizes the current state of research on the effects of nutrigenomics and MedDiet on cardiovascular health. Results suggest that MedDiet, through its impact on gene expression, can positively influence CVH markers such as blood pressure, lipid profile, and inflammation. However, more research is needed to fully understand the complex interactions between genetics, nutrition, and CVH, and to determine the optimal dietary patterns for individualized care. The aim of this scientific review is to evaluate the current evidence on the effects of nutrigenomics and MedDiet on cardiovascular health. The review summarizes the available studies that have investigated the relationship between nutrition, genetics, and cardiovascular health, and explores the mechanisms by which certain dietary patterns can impact CVH outcomes. The review focuses on the effects of MedDiet, a dietary pattern that is rich in whole foods and healthy fats, and its potential to positively influence CVH through its impact on gene expression. The review highlights the limitations of current research and the need for further studies to fully understand the complex interplay between nutrition, genetics, and cardiovascular health.
营养基因组学研究营养与遗传之间的相互作用，以及某些饮食模式如何影响基因表达和整体健康。地中海饮食（MedDiet）以高摄入水果、蔬菜、全谷物和健康脂肪为特征，与更好的心血管健康（CVH）结果相关。本综述总结了营养基因组学和 MedDiet 对心血管健康影响的研究现状。结果表明，MedDiet 通过影响基因表达，可以积极影响 CVH 标志物，如血压、血脂谱和炎症。然而，需要更多的研究来充分了解遗传、营养和 CVH 之间的复杂相互作用，并确定个体化护理的最佳饮食模式。本科学综述的目的是评估营养基因组学和 MedDiet 对心血管健康影响的现有证据。该综述总结了已调查营养、遗传和心血管健康之间关系的现有研究，并探讨了某些饮食模式如何通过影响 CVH 结果来影响 CVH。该综述侧重于 MedDiet 的影响，MedDiet 是一种富含全食物和健康脂肪的饮食模式，通过影响基因表达，有可能对 CVH 产生积极影响。该综述强调了当前研究的局限性以及需要进一步研究以充分了解营养、遗传和心血管健康之间的复杂相互作用。
