Social and Administrative Pharmacy Unit, School of Pharmacy, College of Health Sciences, Addis Ababa University, Zambia Street, P.O. Box: 1176, Addis Ababa, Ethiopia.
Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Health Qual Life Outcomes. 2020 Mar 16;18(1):72. doi: 10.1186/s12955-020-01319-x.
Cancer of the cervix is the most frequent cancer among women in Ethiopia. The disease burden and its treatment adversely affects patients' health-related quality of life (HRQoL). We aimed to investigate the HRQoL and its predictors among cervical cancer patients in Ethiopia.
A hospital-based cross-sectional study was conducted from January to June 2018 at the oncology unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. A total of 404 cervical cancer patients were interviewed using validated Amharic version of the European Organization for Research and Treatment of Cancer module (EORTC QLQ-C30), cervical cancer module (EORTC QLQ-CX24), and Euro Quality of Life Group's 5-Domain Questionnaires 5-Levels (EQ-5D) questionnaires. ANOVA test was used to determine the effect of patients' characteristics on mean scores of the different domains of HRQoL and stepwise multivariable logistic regression was performed to identify predictors of HRQoL. Coefficients of level-specific utility values obtained from a hybrid regression model for the Ethiopian general population were used to compute utility.
The mean age of patients was 52.1 ± 10.4 years and 379 (93.8%) of the patients were receiving service at the outpatient clinic. About one-third (35%) of patients were diagnosed with stage IV cervical cancer. Mean global health status/QoL, mean utility and visual analog scale scores were 48.3 ± 23.77, 0.77 and 65.7 ± 20.83, respectively. Physical functioning (AOR = 4.98, 95% CI:2.16-11.49), emotional functioning (AOR = 5.25, 95% CI:2.26-12.17), pain (AOR = 5.79, 95% CI:2.30-14.57), and symptom experience (AOR = 4.58, 95% CI:1.95-10.79) were associated with patients' HRQoL.
Cervical cancer significantly affects patient's HRQoL and hence, efforts to improve HRQoL should be commenced especially in terms of physical and emotional functioning, pain, and symptom experience.
宫颈癌是埃塞俄比亚女性中最常见的癌症。该疾病的负担及其治疗对患者的健康相关生活质量（HRQoL）产生不利影响。我们旨在研究埃塞俄比亚宫颈癌患者的 HRQoL 及其预测因素。
2018 年 1 月至 6 月，在埃塞俄比亚亚的斯亚贝巴提克里安巴萨专科医院肿瘤科进行了一项基于医院的横断面研究。共有 404 名宫颈癌患者接受了经过验证的阿姆哈拉语版欧洲癌症研究与治疗组织模块（EORTC QLQ-C30）、宫颈癌模块（EORTC QLQ-CX24）和欧洲质量生活组 5 域问卷 5 级（EQ-5D）问卷的访谈。方差分析（ANOVA）用于确定患者特征对不同 HRQoL 领域平均评分的影响，逐步多变量逻辑回归用于确定 HRQoL 的预测因素。从混合回归模型中获得的埃塞俄比亚一般人群的特定水平效用值系数用于计算效用。
患者的平均年龄为 52.1±10.4 岁，其中 379 名（93.8%）患者在门诊就诊。约三分之一（35%）的患者被诊断为 IV 期宫颈癌。全球健康状况/生活质量、平均效用和视觉模拟量表评分分别为 48.3±23.77、0.77 和 65.7±20.83。身体功能（AOR=4.98，95%CI：2.16-11.49）、情绪功能（AOR=5.25，95%CI：2.26-12.17）、疼痛（AOR=5.79，95%CI：2.30-14.57）和症状体验（AOR=4.58，95%CI：1.95-10.79）与患者的 HRQoL 相关。
宫颈癌显著影响患者的 HRQoL，因此应特别关注身体和情绪功能、疼痛和症状体验，努力改善 HRQoL。
