柠檬发酵产品通过调节脂质代谢和肠道微生物群来预防高脂饮食喂养大鼠的肥胖。
Lemon fermented products prevent obesity in high-fat diet-fed rats by modulating lipid metabolism and gut microbiota.
作者信息
Wu Chih-Chung, Huang Yu-Wen, Hou Chih-Yao, Chen Ya-Ting, Dong Cheng-Di, Chen Chiu-Wen, Singhania Reeta Rani, Leang Jie-Yin, Hsieh Shu-Ling
机构信息
Department of Food and Nutrition, Providence University, Taichung, 43301 Taiwan.
Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, 81157 Taiwan.
出版信息
J Food Sci Technol. 2023 Mar;60(3):1036-1044. doi: 10.1007/s13197-022-05445-w. Epub 2022 Apr 13.
(lemon) possesses immunoregulatory, antioxidant, and lipid-lowering effects. Our previous study showed that lemon fermented products (LFP) which were lemon fermented with OPC1 had the ability to avert obesity. However, the LFP effects on the pathway of lipid metabolism by gut microbiota were still unclear. This study was aimed to investigate the LFP effects on liver lipid metabolism and gut microbiota in a rat model of obesity caused by a high-calorie diet. LFP effectively reduced the total triglyceride (49.7%) and total cholesterol (53.3%) contents of the liver. Additionally, the mRNA levels of genes related to triglyceride metabolism (SREBP-1c, PPARγ, and ACC), cholesterol metabolism (HMG-CoA reductase, ACAT, and LCAT), and lipid β-oxidation (PPARα, and CPT-1) were regulated by LFP. Furthermore, LFP reduced the ratio of / and enhanced the ratio of . Overall, these findings suggested that LFP might use as a potential dietary supplement for preventing obesity by modulating the lipid metabolism and improving the gut microbiota.
（柠檬）具有免疫调节、抗氧化和降脂作用。我们之前的研究表明，用OPC1发酵柠檬得到的柠檬发酵产品（LFP）具有预防肥胖的能力。然而，LFP对肠道微生物群脂质代谢途径的影响仍不清楚。本研究旨在探讨LFP对高热量饮食诱导的肥胖大鼠模型肝脏脂质代谢和肠道微生物群的影响。LFP有效降低了肝脏中总甘油三酯（49.7%）和总胆固醇（53.3%）的含量。此外，LFP调节了与甘油三酯代谢（SREBP-1c、PPARγ和ACC）、胆固醇代谢（HMG-CoA还原酶、ACAT和LCAT）以及脂质β-氧化（PPARα和CPT-1）相关基因的mRNA水平。此外，LFP降低了/的比例并提高了/的比例。总体而言，这些发现表明，LFP可能作为一种潜在的膳食补充剂，通过调节脂质代谢和改善肠道微生物群来预防肥胖。
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