Tong Fang, Lin Jian, Zeng Zixuan, Wang Qi, Yang Zhifang, Lv Yehui
School of Basic Medical Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Institute of Wound Prevention and Treatment, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Front Neurol. 2023 Feb 23;14:1139521. doi: 10.3389/fneur.2023.1139521. eCollection 2023.
The mechanism of sudden unexpected death in epilepsy (SUDEP) is elusive and many questions remain unanswered. Autopsy is generally unhelpful in providing evidence for the cause of death, as pathological changes may be on the molecular level. Although histopathological examination occasionally demonstrates pathology such as vascular malformation, old traumatic injury, and tumor, in most cases of SUDEP, the examination is negative. We examined the current status of SUDEP research by performing a bibliometric analysis of studies in the Web of Science Core Collection database published between 2002 and 2022. Our aim was to demonstrate areas of interest and frontiers of SUDEP research. A total of 1803 papers were included in the analysis. The number of published papers focused on SUDEP has been increasing since 2002. Main areas of interest include clinical manifestations, prevalence, treatment, and underlying mechanisms. Research teams from the United States and Europe are leading the way in SUDEP research, while Asia trails behind. Future studies regarding the mechanism and neuropathology of SUDEP are warranted.
癫痫性猝死（SUDEP）的机制尚不清楚，许多问题仍未得到解答。尸检通常无助于提供死亡原因的证据，因为病理变化可能处于分子水平。尽管组织病理学检查偶尔会显示出诸如血管畸形、陈旧性创伤损伤和肿瘤等病理情况，但在大多数SUDEP病例中，检查结果为阴性。我们通过对2002年至2022年期间发表在科学网核心合集数据库中的研究进行文献计量分析，来审视SUDEP研究的现状。我们的目的是展示SUDEP研究的热点领域和前沿。分析共纳入1803篇论文。自2002年以来，关注SUDEP的已发表论文数量一直在增加。主要关注领域包括临床表现、患病率、治疗和潜在机制。美国和欧洲的研究团队在SUDEP研究中处于领先地位，而亚洲则落后。有必要对SUDEP的机制和神经病理学进行进一步研究。
