• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Can the entorhinal cortex help distinguish healthy aging brains from pathological aging brains?

作者信息

Takashima Akihiko, Koike Riki, Soeda Yoshiyuki

机构信息

Laboratory for Alzheimer's Disease, Department of Life Science, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan.

出版信息

Aging Brain. 2022 Jan 5;2:100026. doi: 10.1016/j.nbas.2021.100026. eCollection 2022.

DOI:10.1016/j.nbas.2021.100026
PMID:36908878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9999443/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55eb/9999443/0d05684723b6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55eb/9999443/90e0fd840ad4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55eb/9999443/7f3ed4e83bfe/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55eb/9999443/0d05684723b6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55eb/9999443/90e0fd840ad4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55eb/9999443/7f3ed4e83bfe/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55eb/9999443/0d05684723b6/gr3.jpg

相似文献

1
Can the entorhinal cortex help distinguish healthy aging brains from pathological aging brains?内嗅皮质能否帮助区分健康衰老大脑和病理性衰老大脑?
Aging Brain. 2022 Jan 5;2:100026. doi: 10.1016/j.nbas.2021.100026. eCollection 2022.
2
Network activity changes in the pathophysiology of Alzheimer's disease: the role of aging and early entorhinal cortex dysfunction.阿尔茨海默病病理生理学中的网络活动变化:衰老和早期内嗅皮层功能障碍的作用。
Metab Brain Dis. 2022 Feb;37(2):289-298. doi: 10.1007/s11011-021-00848-8. Epub 2021 Sep 30.
3
Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease.临床前阿尔茨海默病中内嗅皮层和CA1区的神经元数量
Arch Neurol. 2001 Sep;58(9):1395-402. doi: 10.1001/archneur.58.9.1395.
4
[Brain volumetric MRI study in healthy elderly persons using statistical parametric mapping].[使用统计参数映射对健康老年人进行脑容积磁共振成像研究]
Seishin Shinkeigaku Zasshi. 2004;106(2):138-51.
5
Alzheimer's disease severely affects areas of the claustrum connected with the entorhinal cortex.阿尔茨海默病严重影响与内嗅皮质相连的屏状核区域。
J Hirnforsch. 1996;37(2):173-80.
6
Single-cell analysis reveals transcriptomic reprogramming in aging primate entorhinal cortex and the relevance with Alzheimer's disease.单细胞分析揭示了衰老灵长类动物内嗅皮层中转录组的重编程及其与阿尔茨海默病的相关性。
Aging Cell. 2022 Nov;21(11):e13723. doi: 10.1111/acel.13723. Epub 2022 Sep 27.
7
Path integration in normal aging and Alzheimer's disease.正常衰老和阿尔茨海默病中的路径整合。
Trends Cogn Sci. 2022 Feb;26(2):142-158. doi: 10.1016/j.tics.2021.11.001. Epub 2021 Dec 3.
8
Conservation of neuron number and size in entorhinal cortex layers II, III, and V/VI of aged primates.老年灵长类动物内嗅皮层第II、III和V/VI层中神经元数量和大小的守恒
J Comp Neurol. 2000 Jul 3;422(3):396-401. doi: 10.1002/1096-9861(20000703)422:3<396::aid-cne6>3.0.co;2-r.
9
Regional and Gender Study of Neuronal Density in Brain during Aging and in Alzheimer's Disease.衰老及阿尔茨海默病期间大脑神经元密度的区域及性别研究
Front Aging Neurosci. 2016 Sep 13;8:213. doi: 10.3389/fnagi.2016.00213. eCollection 2016.
10
The role of the entorhinal cortex in extinction: influences of aging.内嗅皮质在消退中的作用:衰老的影响。
Neural Plast. 2008;2008:595282. doi: 10.1155/2008/595282.

引用本文的文献

1
Research on the molecular mechanism of singularity phenomenon in neurological disorders.神经系统疾病中奇异现象的分子机制研究。
Biophys Physicobiol. 2024 Feb 15;21(Supplemental):e211008. doi: 10.2142/biophysico.bppb-v21.s008. eCollection 2024.

本文引用的文献

1
New Insights Into Drug Discovery Targeting Tau Protein.靶向tau蛋白的药物发现新见解。
Front Mol Neurosci. 2020 Dec 3;13:590896. doi: 10.3389/fnmol.2020.590896. eCollection 2020.
2
Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding.用于边界编码的以自我为中心与以环境为中心转换的内嗅- retrosplenial回路
Elife. 2020 Nov 3;9:e59816. doi: 10.7554/eLife.59816.
3
Functional connectivity between the entorhinal and posterior cingulate cortices underpins navigation discrepancies in at-risk Alzheimer's disease.
内侧嗅皮层和后扣带回皮层之间的功能连接为阿尔茨海默病高危人群的导航差异提供了基础。
Neurobiol Aging. 2020 Jun;90:110-118. doi: 10.1016/j.neurobiolaging.2020.02.007. Epub 2020 Feb 19.
4
Enhanced Tau Protein Translation by Hyper-Excitation.通过过度兴奋增强tau蛋白翻译
Front Aging Neurosci. 2019 Nov 20;11:322. doi: 10.3389/fnagi.2019.00322. eCollection 2019.
5
Neurons and networks in the entorhinal cortex: A reappraisal of the lateral and medial entorhinal subdivisions mediating parallel cortical pathways.内嗅皮层中的神经元和神经网络:重新评估介导平行皮质通路的外侧和内侧内嗅皮层亚区。
Hippocampus. 2019 Dec;29(12):1238-1254. doi: 10.1002/hipo.23145. Epub 2019 Aug 13.
6
Reorganization of brain networks and its association with general cognitive performance over the adult lifespan.大脑网络的重组及其与成年后整体认知表现的关联。
Sci Rep. 2019 Aug 6;9(1):11352. doi: 10.1038/s41598-019-47922-x.
7
Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer's disease.阿尔茨海默病患者经淀粉样蛋白-β免疫接种 14 年后仍存在神经病理学影响。
Brain. 2019 Jul 1;142(7):2113-2126. doi: 10.1093/brain/awz142.
8
Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation.使用基于内嗅皮层的虚拟现实导航测试来区分轻度认知障碍。
Brain. 2019 Jun 1;142(6):1751-1766. doi: 10.1093/brain/awz116.
9
Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer's Disease.阿他贝司他在临床前阿尔茨海默病试验中的初步结果。
N Engl J Med. 2019 Apr 11;380(15):1483-1485. doi: 10.1056/NEJMc1813435.
10
Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease.随机试验:维鲁贝司他治疗前驱阿尔茨海默病。
N Engl J Med. 2019 Apr 11;380(15):1408-1420. doi: 10.1056/NEJMoa1812840.