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Research on the molecular mechanism of singularity phenomenon in neurological disorders.

作者信息

Bannai Hiroko, Takashima Akihiko, Soeda Yoshiyuki, Yoshimura Hideaki, Matsumoto Gen, Sahara Naruhiko, Hiroshima Michio, Hattori Mitsuru, Nagai Takeharu

机构信息

School of Advanced Science and Engineering, Department of Electrical Engineering and Biosciences, Waseda University, Shinjuku-Ku, Tokyo 162-0056, Japan.

Laboratory for Alzheimer's Disease, Department of Life Science, Faculty of Science, Gakushuin University, Toshima-ku, Tokyo 171-8588, Japan.

出版信息

Biophys Physicobiol. 2024 Feb 15;21(Supplemental):e211008. doi: 10.2142/biophysico.bppb-v21.s008. eCollection 2024.

DOI:10.2142/biophysico.bppb-v21.s008
PMID:39175863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11338678/
Abstract
摘要

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Intracellular tau fragment droplets serve as seeds for tau fibrils.细胞内 tau 片段液滴可作为 tau 纤维的种子。
Structure. 2024 Oct 3;32(10):1793-1807.e6. doi: 10.1016/j.str.2024.06.018. Epub 2024 Jul 19.
2
Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex.路径整合缺陷与内嗅皮质中磷酸化tau蛋白的积累有关。
Brain Commun. 2024 Feb 12;6(1):fcad359. doi: 10.1093/braincomms/fcad359. eCollection 2024.
3
Propagative α-synuclein seeds as serum biomarkers for synucleinopathies.传播性 α-突触核蛋白种子作为突触核蛋白病的血清生物标志物。
Nat Med. 2023 Jun;29(6):1448-1455. doi: 10.1038/s41591-023-02358-9. Epub 2023 May 29.
4
Can the entorhinal cortex help distinguish healthy aging brains from pathological aging brains?内嗅皮质能否帮助区分健康衰老大脑和病理性衰老大脑?
Aging Brain. 2022 Jan 5;2:100026. doi: 10.1016/j.nbas.2021.100026. eCollection 2022.
5
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy.p62/SQSTM1 在tau 病小鼠模型中清除毒性 tau 种属的核心作用。
Aging Cell. 2022 Jul;21(7):e13615. doi: 10.1111/acel.13615. Epub 2022 Jun 5.
6
Entorhinal Subfield Vulnerability to Neurofibrillary Tangles in Aging and the Preclinical Stage of Alzheimer's Disease.衰老和阿尔茨海默病临床前阶段的内嗅皮层亚区对神经纤维缠结的易感性。
J Alzheimers Dis. 2022;87(3):1379-1399. doi: 10.3233/JAD-215567.
7
Large-scale single-molecule imaging aided by artificial intelligence.借助人工智能的大规模单分子成像
Microscopy (Oxf). 2020 Apr 8;69(2):69-78. doi: 10.1093/jmicro/dfz116.
8
Enhanced Tau Protein Translation by Hyper-Excitation.通过过度兴奋增强tau蛋白翻译
Front Aging Neurosci. 2019 Nov 20;11:322. doi: 10.3389/fnagi.2019.00322. eCollection 2019.
9
Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau.通过免疫印迹、蛋白质序列以及对 Sarkosyl 不溶性和胰蛋白酶抗性 tau 的质谱分析对 tau 蛋白病进行生化分类。
Acta Neuropathol. 2016 Feb;131(2):267-280. doi: 10.1007/s00401-015-1503-3. Epub 2015 Nov 4.
10
Proteopathic tau seeding predicts tauopathy in vivo.蛋白病性tau种子在体内可预测tau蛋白病。
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4376-85. doi: 10.1073/pnas.1411649111. Epub 2014 Sep 26.