Chen Zeru, Wu Zichun, Zhang Yuying
Department of Clinical Medicine, The Second School of Clinical Medicine, Guangzhou Medical University, Guangzhou, China.
Department of Clinical Medicine, The First School of Clinical Medicine, Guangzhou Medical University, Guangzhou, China.
Front Nutr. 2024 Aug 7;11:1430730. doi: 10.3389/fnut.2024.1430730. eCollection 2024.
Pelvic inflammatory disease (PID) is a common gynecological condition associated with significant morbidity and healthcare costs. Emerging evidence suggests that dietary factors, such as magnesium intake, may play a role in PID risk. However, the relationship between dietary magnesium intake and PID risk remains uncertain. This cross-sectional study aimed to investigate the association between dietary magnesium intake and the risk of PID.
This cross-sectional study included data from the National Health and Nutrition Examination Survey (NHANES) 2015-2018. Weighted multivariable logistic regression was used to examine the association between dietary magnesium intake and PID. Restricted cubic spline (RCS) analysis was performed to assess the linear and non-linear associations. Subgroup analyses were performed based on baseline characteristics.
A total of 3,034 women aged 20-59 were included in the study. Magnesium intake exhibited a significant association with lower PID risk in weighted multivariable logistic regression. Adjusted odds ratios (ORs) for dietary magnesium intake in quartiles Q2 (133.12-214.93 mg/day), Q3 (214.93-287.19 mg/day), and Q4 (above 287.19 mg/day) compared to Q1 (below 133.12 mg/day) were 0.48 (95% CI: 0.28-0.82), 0.64 (95% CI: 0.32-1.27), and 0.40 (95% CI: 0.18-0.88), respectively. Stratified analyses showed that significant association between dietary magnesium intake and PID in older subgroup but not in younger subgroup. Additionally, RCS analyses consistently revealed a linear negative correlation between dietary magnesium intake and PID risk.
This study reveals a significant negative correlation between dietary magnesium intake and risk of PID, particularly among older individuals. These findings underscore the importance of dietary factors in gynecological health and highlight the potential role of magnesium supplementation in PID prevention strategies.
盆腔炎（PID）是一种常见的妇科疾病，会导致较高的发病率和医疗成本。新出现的证据表明，饮食因素，如镁的摄入量，可能在PID风险中起作用。然而，饮食中镁的摄入量与PID风险之间的关系仍不确定。这项横断面研究旨在调查饮食中镁的摄入量与PID风险之间的关联。
这项横断面研究纳入了2015 - 2018年美国国家健康与营养检查调查（NHANES）的数据。采用加权多变量逻辑回归来检验饮食中镁的摄入量与PID之间的关联。进行受限立方样条（RCS）分析以评估线性和非线性关联。根据基线特征进行亚组分析。
该研究共纳入了3034名年龄在20 - 59岁的女性。在加权多变量逻辑回归中，镁的摄入量与较低的PID风险呈现出显著关联。与第一四分位数（低于133.12毫克/天）相比，第二四分位数（133.12 - 214.93毫克/天）、第三四分位数（214.93 - 287.19毫克/天）和第四四分位数（高于287.19毫克/天）的饮食镁摄入量的调整比值比（OR）分别为0.48（95%置信区间：0.28 - 0.82）、0.64（95%置信区间：0.32 - 1.27）和0.40（95%置信区间：0.18 - 0.88）。分层分析表明，饮食中镁的摄入量与PID之间的显著关联在年龄较大的亚组中存在，而在年龄较小的亚组中不存在。此外，RCS分析一致显示饮食中镁的摄入量与PID风险之间存在线性负相关。
本研究揭示了饮食中镁的摄入量与PID风险之间存在显著的负相关，尤其是在老年人中。这些发现强调了饮食因素在妇科健康中的重要性，并突出了补充镁在PID预防策略中的潜在作用。
