因创伤行脾切除术患者的外周血白细胞亚群
Peripheral blood leucocyte subpopulations in patients splenectomized for trauma.
作者信息
Ferrante A, Drew P A, Kiroff G K, Zola H
机构信息
University Department of Paediatrics, Adelaide Children's Hospital, South Australia.
出版信息
Clin Exp Immunol. 1987 Oct;70(1):158-63.
Monoclonal antibodies were used to type leucocyte subpopulations in peripheral blood mononuclear leucocytes (MNL) from patients who had had spleens removed following trauma. The proportion of OKT3+ (T) cell and OKT4+ ('T helper/inducer') cell was significantly decreased in splenectomized subjects. While a decrease was also observed for the OKT8+ ('T suppressor/cytotoxic') cells, this was not significant. The ratio of OKT4+/OKT8+ cells was significantly decreased in the splenectomized group. Interestingly, the absolute numbers of OKT3+, OKT4+ and OKT8+ cells were increased. The % of B lymphocytes (identified as Ig+ and FMC1+ cells) was significantly increased in patients. The proportion of MHC Class II+ cells (FMC4+) was also increased although not significantly. A marked increase in % of monocytes (FMC33+) was observed in patients. The changes in proportion of regulatory T cells and monocytes may in part explain the depressed mitogen responses of MNL from splenectomized subjects.
使用单克隆抗体对因外伤而切除脾脏的患者外周血单个核白细胞（MNL）中的白细胞亚群进行分型。脾切除患者中OKT3 +（T）细胞和OKT4 +（“T辅助/诱导”）细胞的比例显著降低。虽然OKT8 +（“T抑制/细胞毒性”）细胞也有减少，但不显著。脾切除组中OKT4 + / OKT8 +细胞的比例显著降低。有趣的是，OKT3 +、OKT4 +和OKT8 +细胞的绝对数量增加。患者中B淋巴细胞（鉴定为Ig +和FMC1 +细胞）的百分比显著增加。MHC II类+细胞（FMC4 +）的比例也有所增加，尽管不显著。患者中单核细胞（FMC33 +）的百分比显著增加。调节性T细胞和单核细胞比例的变化可能部分解释了脾切除患者MNL的丝裂原反应降低的原因。
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