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使用离散广义帕累托分布对SARS-CoV-2社区传播进行极值建模。

Extreme value modelling of SARS-CoV-2 community transmission using discrete generalized Pareto distributions.

作者信息

Daouia Abdelaati, Stupfler Gilles, Usseglio-Carleve Antoine

机构信息

Toulouse School of Economics, University of Toulouse Capitole, Toulouse, France.

University of Angers, CNRS, LAREMA, SFR MATHSTIC, 49000 Angers, France.

出版信息

R Soc Open Sci. 2023 Mar 8;10(3):220977. doi: 10.1098/rsos.220977. eCollection 2023 Mar.

DOI:10.1098/rsos.220977
PMID:36908992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9993046/
Abstract

Superspreading has been suggested to be a major driver of overall transmission in the case of SARS-CoV-2. It is, therefore, important to statistically investigate the tail features of superspreading events (SSEs) to better understand virus propagation and control. Our extreme value analysis of different sources of secondary case data indicates that case numbers of SSEs associated with SARS-CoV-2 may be fat-tailed, although substantially less so than predicted recently in the literature, but also less important relative to SSEs associated with SARS-CoV. The results caution against pooling data from both coronaviruses. This could provide policy- and decision-makers with a more reliable assessment of the tail exposure to SARS-CoV-2 contamination. Going further, we consider the broader problem of large community transmission. We study the tail behaviour of SARS-CoV-2 cluster cases documented both in official reports and in the media. Our results suggest that the observed cluster sizes have been fat-tailed in the vast majority of surveyed countries. We also give estimates and confidence intervals of the extreme potential risk for those countries. A key component of our methodology is up-to-date discrete generalized Pareto models which allow for maximum likelihood-based inference of data with a high degree of discreteness.

摘要

在新冠病毒(SARS-CoV-2)的情况下,超级传播被认为是总体传播的主要驱动因素。因此,从统计学角度研究超级传播事件(SSE)的尾部特征对于更好地理解病毒传播和控制至关重要。我们对不同来源的二代病例数据进行的极值分析表明,与SARS-CoV-2相关的SSE的病例数可能是厚尾分布,尽管比最近文献中预测的要少得多,但相对于与SARS-CoV相关的SSE也不那么重要。结果警示不要将两种冠状病毒的数据合并。这可以为政策制定者和决策者提供对SARS-CoV-2污染尾部暴露的更可靠评估。进一步而言,我们考虑了更大范围的社区传播问题。我们研究了官方报告和媒体中记录的SARS-CoV-2聚集性病例的尾部行为。我们的结果表明,在绝大多数接受调查的国家中,观察到的聚集性病例规模呈厚尾分布。我们还给出了这些国家极端潜在风险的估计值和置信区间。我们方法的一个关键组成部分是最新的离散广义帕累托模型,该模型允许对具有高度离散性的数据进行基于最大似然的推断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/ab2df078fd05/rsos220977f09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/3b7b6890e6f5/rsos220977f01.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/0c8ebe2ea2f4/rsos220977f05.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/63d0e724cb4c/rsos220977f08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/ab2df078fd05/rsos220977f09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/3b7b6890e6f5/rsos220977f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/f3e5f2a52cc4/rsos220977f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/0125642ddbd3/rsos220977f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/0d2ce4779e3d/rsos220977f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/0c8ebe2ea2f4/rsos220977f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/3f3691c83fb0/rsos220977f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/9cfb302048f6/rsos220977f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/63d0e724cb4c/rsos220977f08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e772/9993046/ab2df078fd05/rsos220977f09.jpg

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Serial Interval and Transmission Dynamics during SARS-CoV-2 Delta Variant Predominance, South Korea.在韩国,SARS-CoV-2 德尔塔变异株占主导地位期间的连续间隔和传播动力学。
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