Pozzetto B, Genin C, Gaudin O G, Berthoux F C, Alloin B, Laurent B, Ros A
Laboratory of Virology, Faculty of Medicine, Saint-Etienne, France.
Clin Nephrol. 1987 Oct;28(4):194-8.
Twenty-one patients with chronic glomerulonephritis (GN) (5 with renal failure) received three doses of live trivalent poliovirus vaccine administered orally. The effect of the polio vaccination on the renal function and the titers of antibodies to poliovirus were studied. No significant consequence was observed in renal disease. Before vaccination, titers of poliovirus type 1 and 3 antibodies were significantly decreased as compared to healthy adult subjects. After vaccination, the patients exhibited a significant rise in poliovirus antibody titers for the three serotypes, although some of them failed to develop a fourfold or greater antibody rise to at least one of the three serotypes, especially in the group of patients with renal failure. These results indicate that live poliovirus vaccination is not deleterious in patients with GN and can provide a good protection.
21例慢性肾小球肾炎（GN）患者（5例为肾衰竭患者）口服了三剂三价脊髓灰质炎减毒活疫苗。研究了脊髓灰质炎疫苗接种对肾功能和脊髓灰质炎病毒抗体滴度的影响。未观察到对肾脏疾病有显著影响。接种疫苗前，与健康成人相比，1型和3型脊髓灰质炎病毒抗体滴度显著降低。接种疫苗后，患者三种血清型的脊髓灰质炎病毒抗体滴度均显著升高，尽管其中一些患者对三种血清型中至少一种的抗体未出现四倍或更高的升高，尤其是在肾衰竭患者组中。这些结果表明，脊髓灰质炎减毒活疫苗接种对GN患者无害，且能提供良好的保护。
