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一名转移性肺癌患者的复发性中风

Recurrent Strokes in a Patient With Metastatic Lung Cancer.

作者信息

Karkra Rohan, Jain Riya, Shivaswamy Rajendra P

机构信息

Medicine, JSS (Jagadguru Sri Shivarathreeshwara) Medical College and Hospital, JSSAHER (JSS Academy of Higher Education and Research), Mysuru, IND.

Internal Medicine, JSS (Jagadguru Sri Shivarathreeshwara) Medical College and Hospital, JSSAHER (JSS Academy of Higher Education and Research), Mysuru, IND.

出版信息

Cureus. 2023 Feb 6;15(2):e34699. doi: 10.7759/cureus.34699. eCollection 2023 Feb.

DOI:10.7759/cureus.34699
PMID:36909080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9995248/
Abstract

A stroke, also known as cerebrovascular accident (CVA), is a medical condition that occurs when the blood supply to the brain is interrupted, resulting in brain cell death. Cancer-associated stroke (CAS) is a rare but serious complication of cancer, where a malignant tumor or its metastases invade or compress the blood vessels in the brain, resulting in a stroke. We describe a case of a 60-year-old male patient recently diagnosed with lung cancer with metastasis to the liver, esophagus, small intestine, and pancreas who has had at least three CVAs within a span of three months. He developed sequelae such as hemiplegia and aphasia. He was managed with dual antiplatelet therapy, neuroprotective drugs, and physiotherapy. Patients with advanced cancers should be routinely screened for neurovascular complications and risks. Prophylactic therapy should be started wherever warranted.

摘要

中风,也称为脑血管意外(CVA),是一种当大脑血液供应中断导致脑细胞死亡时发生的病症。癌症相关性中风(CAS)是癌症罕见但严重的并发症,恶性肿瘤或其转移灶侵入或压迫脑内血管,导致中风。我们描述了一例60岁男性患者,最近被诊断为肺癌并已转移至肝脏、食管、小肠和胰腺,在三个月内至少发生了三次脑血管意外。他出现了偏瘫和失语等后遗症。对其采用双重抗血小板治疗、神经保护药物和物理治疗。晚期癌症患者应常规筛查神经血管并发症和风险。只要有必要,就应开始预防性治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03b4/9995248/88ac0b8771c5/cureus-0015-00000034699-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03b4/9995248/eca93333e8c6/cureus-0015-00000034699-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03b4/9995248/4a1b5d2f3da1/cureus-0015-00000034699-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03b4/9995248/fd3f92f7bf25/cureus-0015-00000034699-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03b4/9995248/88ac0b8771c5/cureus-0015-00000034699-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03b4/9995248/eca93333e8c6/cureus-0015-00000034699-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03b4/9995248/4a1b5d2f3da1/cureus-0015-00000034699-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03b4/9995248/fd3f92f7bf25/cureus-0015-00000034699-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03b4/9995248/88ac0b8771c5/cureus-0015-00000034699-i04.jpg

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本文引用的文献

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Cancer-related stroke: Exploring personalized therapy strategies.癌症相关中风:探索个性化治疗策略。
Brain Behav. 2022 Sep;12(9):e2738. doi: 10.1002/brb3.2738. Epub 2022 Aug 8.
2
Cancer-Related Stroke: An Emerging Subtype of Ischemic Stroke with Unique Pathomechanisms.癌症相关卒中:一种具有独特发病机制的新型缺血性卒中亚型
J Stroke. 2020 Jan;22(1):1-10. doi: 10.5853/jos.2019.02278. Epub 2020 Jan 31.
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Efficacy of Neuroprotective Drugs in Acute Ischemic Stroke: Is It Helpful?神经保护药物在急性缺血性卒中中的疗效:是否有益?
J Neurosci Rural Pract. 2019 Oct;10(4):576-581. doi: 10.1055/s-0039-1700790. Epub 2019 Dec 11.
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International clinical practice guidelines including guidance for direct oral anticoagulants in the treatment and prophylaxis of venous thromboembolism in patients with cancer.国际临床实践指南,包括癌症患者静脉血栓栓塞症治疗和预防中直接口服抗凝剂的指南。
Lancet Oncol. 2016 Oct;17(10):e452-e466. doi: 10.1016/S1470-2045(16)30369-2.
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Procoagulant effects of lung cancer chemotherapy: impact on microparticles and cell-free DNA.肺癌化疗的促凝作用:对微粒和游离DNA的影响
Blood Coagul Fibrinolysis. 2017 Jan;28(1):72-82. doi: 10.1097/MBC.0000000000000546.
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