Department of Neurological Rehabilitation, Xuzhou Central Hospital, Xuzhou city, P.R. China.
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou city, P.R. China.
Brain Behav. 2022 Sep;12(9):e2738. doi: 10.1002/brb3.2738. Epub 2022 Aug 8.
Cancer and ischemic stroke are two common diseases that threaten human health and have become the main causes of death in the world. It is estimated that one-in-ten patients with ischemic stroke have concomitant cancer, and this incidence is expected to increase as improvements in medical technology extends the life expectancy of cancer patients.
Cancer-related stroke (CRS) refers to unexplained ischemic stroke in patients with active cancer that cannot be explained by current stroke mechanisms. Available evidence suggests that CRS accounts for 5-10% of embolic stroke of undetermined source (ESUS). Although the incidence of CRS is gradually increasing, its underlying pathogenesis remains unclear. Also, there is no consensus on acute treatment and secondary prevention of stroke.
In this review, we retrospectively analyzed the incidence, mechanisms of CRS, its potential as a new stroke subtype, options for acute treatment, secondary prevention strategies, and disease progression, with the aim of attempting to explore personalized therapy strategies.
癌症和缺血性中风是两种常见的疾病，严重威胁着人类的健康，已成为世界范围内的主要致死病因。据估计，十分之一的缺血性中风患者同时患有癌症，并且随着医疗技术的进步延长了癌症患者的预期寿命，这一发病率预计将会增加。
癌症相关卒中（CRS）是指在患有活动性癌症的患者中出现的无法用目前的卒中机制解释的不明原因的缺血性卒中。现有证据表明，CRS 占不明来源栓塞性卒中（ESUS）的 5-10%。尽管 CRS 的发病率逐渐增加，但其潜在发病机制尚不清楚。此外，急性卒中治疗和二级预防的方法也没有达成共识。
在这篇综述中，我们回顾性地分析了 CRS 的发生率、发病机制、其作为一种新的卒中亚型的潜在可能、急性治疗的选择、二级预防策略以及疾病进展，旨在尝试探索个性化的治疗策略。
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