Munir Zaid, Akash Muhammad, Jaiprada Fnu, Abu Tarboush Bilal, Ijaz Osama, Bseiso Anan, Palleti Sujith K, Amin Adil
General Medicine, Withybush General Hospital, Cardiff, GBR.
Clinical Sciences, Mayo Hospital, King Edward Medical University, Lahore, PAK.
Cureus. 2023 Feb 7;15(2):e34729. doi: 10.7759/cureus.34729. eCollection 2023 Feb.
The aim of this meta-analysis is to assess the efficacy of extracorporeal shockwave therapy (ESWT) in patients with peripheral arterial disease (PAD). This meta-analysis was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search was conducted independently by two authors using PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to January 15, 2023. Primary clinical outcomes assessed in this meta-analysis were changes in maximum waking distance (MWD) and pain-free walking distance (PFWD) from baseline. Other outcomes assessed included change in ankle brachial pressure index (ABI) and degree of arterial stenosis. Four RCTs involving a total of 228 patients were included. Change of PFWD and MWD from baseline was significantly higher in patients randomized in the ESWT group as compared to the control group. No significant differences were reported between the two groups in terms of change in ABI from baseline. In conclusion, this meta-analysis of four randomized controlled trials found evidence that ESWT is an effective treatment for patients with PAD in terms of improving PFWD and MWD and reducing stenosis. However, there was no significant difference in the improvement of the ankle-brachial index between the study groups.
本荟萃分析的目的是评估体外冲击波疗法（ESWT）对周围动脉疾病（PAD）患者的疗效。本荟萃分析按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行。两位作者独立使用PubMed、EMBASE和Cochrane对照试验中央注册库（CENTRAL）从建库至2023年1月15日进行了系统检索。本荟萃分析评估的主要临床结局是自基线起最大步行距离（MWD）和无痛步行距离（PFWD）的变化。评估的其他结局包括踝肱压力指数（ABI）的变化和动脉狭窄程度。纳入了4项随机对照试验，共228例患者。与对照组相比，ESWT组随机分组患者自基线起的PFWD和MWD变化显著更高。两组自基线起的ABI变化无显著差异。总之，这项对4项随机对照试验的荟萃分析发现，有证据表明ESWT在改善PFWD和MWD以及减轻狭窄方面是治疗PAD患者的有效方法。然而，各研究组之间在踝肱指数改善方面无显著差异。
