Hadrach Safaa, Benazzouz Imane
Laboratory of Chemistry-Biochemistry, Environment, Nutrition, and Health, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca 5696, Morocco.
Biochemistry Laboratory, CHU Ibn Rochd of Casablanca, Morocco.
Int J Pediatr. 2023 Mar 2;2023:7985231. doi: 10.1155/2023/7985231. eCollection 2023.
Serum protein electrophoresis is a simple, reliable, and specific method used for separation of serum proteins. This study consisted to detect, at pediatric cases, pathological profiles of serum proteins by capillary electrophoresis and interpret any anomalies. The study was performed on 81 sera collected from pediatric subjects admitted at the Abderrahim Harouchi Children's Hospital in Casablanca. Study results revealed 72 specific pathological electrophoretic patterns for acute and chronic inflammatory response (35 children), hypogammaglobulinemia (3), polyclonal hypergammaglobulinemia (23), hypoalbuminemia (5), agammaglobulinemia (1), and other medical conditions (2). No cases of alpha-1-antitrypsin deficiency and nephrotic syndrome by electrophoresis were highlighted. Serum protein electrophoresis in children is recommended as a diagnostic technique for increasing the accuracy of the diagnosis in acute, subacute, and chronic inflammatory diseases, liver disease, and cases of immunodeficiency.
血清蛋白电泳是一种用于分离血清蛋白的简单、可靠且特异的方法。本研究旨在通过毛细管电泳检测儿科病例血清蛋白的病理图谱，并解读任何异常情况。该研究对从卡萨布兰卡阿卜杜勒拉希姆·哈鲁奇儿童医院收治的儿科受试者采集的81份血清进行。研究结果揭示了急性和慢性炎症反应（35名儿童）、低丙种球蛋白血症（3例）、多克隆高丙种球蛋白血症（23例）、低白蛋白血症（5例）、无丙种球蛋白血症（1例）及其他病症（2例）的72种特定病理电泳图谱。未发现通过电泳检测出α-1抗胰蛋白酶缺乏症和肾病综合征的病例。推荐将儿童血清蛋白电泳作为一种诊断技术，以提高急性、亚急性和慢性炎症性疾病、肝脏疾病及免疫缺陷病例诊断的准确性。
