Constantin Adrian, Constantinoiu Silviu, Achim Florin, Socea Bogdan, Costea Daniel Ovidiu, Predescu Dragos
General and Esophageal Clinic, Sf. Maria Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Department of Surgery, Sf. Pantelimon Emergency Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
J Thorac Dis. 2023 Feb 28;15(2):759-779. doi: 10.21037/jtd-22-861. Epub 2023 Jan 31.
Esophageal diverticulum (ED) is a relatively rare condition, characterized by high etio- and pathophysiological versatility, with an uncommon clinical impact, consequently requiring a complete and complex diagnostic evaluation, so that the therapeutic decision is "appropriate" to a specific case. The aim of the paper is, therefore, a reassessment of the diagnostic possibilities underlying the establishment of the therapeutic protocol and the available therapeutic resources, making a review of the literature, and a non-statistical retrospective analysis of cases hospitalized and operated in a tertiary center.
Thus, classical investigations (upper digestive endoscopy, barium swallow) need to be correlated with complex, manometric, and imaging evaluations with direct implications in therapeutic management. Moreover, in the absence of a precise etiology, the operative indication needs to be established sparingly, with the imposition of the identification and interception of the pathophysiological mechanisms through the therapeutic gesture.
The identification of the pathophysiological mechanisms is mandatory for the management of diverticular disease, the result obtained-restoring swallowing and comfort/good quality of life in the postoperative period-is directly related to the chosen therapeutic procedure. In addition, management appears to be a difficult goal in the context of the low incidence of ED but also of the results that emphasize important differences in the reports in the medical literature. Although ED is a benign condition, surgical techniques are demanding, impacted by significant morbidity and mortality. The causes of these results are multiple: possible localizations anywhere in the esophagus, diverticulum size/volume from a few millimeters to an impressive one, over 10-12 cm, metabolic impact in direct relation to the alteration swallowing, numerous diverticular complications but, perhaps most importantly, alteration of the quality of the diverticular wall by inflammatory phenomena, with an impact on the quality of the suture.
The accumulation of cases in a tertiary profile center, with volume/hospital, respectively volume/surgeon + gastroenterologist could be a solution in improving the results. One consequence would be the identification of alternative solutions to open surgical techniques, a series of minimally invasive or endoscopic variants can refine these results.
食管憩室(ED)是一种相对罕见的疾病,其病因和病理生理具有高度多样性,临床影响不常见,因此需要进行全面而复杂的诊断评估,以便针对具体病例做出“恰当”的治疗决策。因此,本文旨在重新评估制定治疗方案所依据的诊断可能性以及现有的治疗资源,对文献进行综述,并对在三级中心住院并接受手术的病例进行非统计学回顾性分析。
因此,经典检查(上消化道内镜检查、吞钡造影)需要与复杂的测压和影像学评估相结合,这些评估对治疗管理有直接影响。此外,在病因不明确的情况下,手术指征的确定需要谨慎,通过治疗手段识别和阻断病理生理机制。
识别病理生理机制对于憩室病的管理至关重要,所获得的结果——恢复吞咽功能以及术后舒适度/良好的生活质量——与所选治疗方法直接相关。此外,鉴于食管憩室发病率较低,且医学文献报道的结果存在显著差异,管理似乎是一个难题。尽管食管憩室是一种良性疾病,但手术技术要求高,且存在显著的发病率和死亡率。这些结果的原因是多方面的:憩室可能位于食管的任何部位,大小从几毫米到超过10 - 12厘米不等,代谢影响与吞咽改变直接相关,有许多憩室并发症,但也许最重要的是,炎症现象会改变憩室壁的质量,进而影响缝合质量。
在三级专科中心积累病例,分别按医院容量/病例数以及外科医生 + 胃肠病学家的容量/病例数积累病例,可能是改善治疗结果的一种解决方案。一个结果将是确定开放手术技术的替代方案,一系列微创或内镜变体可以改善这些结果。