Abd El Wahab Wegdan M, Ali Mona I, Ibrahim Shimaa S, Mohamed Yasmen A, Hamdy Doaa A
Department of Medical Parasitology, College of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Department of Pediatrics, College of Medicine, Beni-Suef University, Beni-Suef, Egypt.
J Parasit Dis. 2023 Mar;47(1):93-100. doi: 10.1007/s12639-022-01543-w. Epub 2022 Oct 29.
Toxocariasis is an underestimated geohelminthic infection which shows respiratory changes concurrent with larval migration. The purpose of the present study was to detect seropositivity in asthmatic and pneumonic children, and in turn to evaluate its association with the children clinical manifestations, laboratory test results, and sociodemographic risk factors. A total of 50 asthmatic, 50 pneumonic children and 50 healthy controls were subjected to stool analysis by direct wet mount and concentration techniques to exclude possible cross reactivity. Blood samples were collected for complete blood count and assessment of eosinophil count. Sera were examined for anti- IgG antibodies, and measurement of total IgE level. Anti IgG was detected in 27.3% (41/150) of the studied children. It was significantly higher in asthmatic group compared to controls (26%. value = 0.033) and significantly highest in pneumonia group compared to both bronchial asthma group (46%. value = 0.030) and control group (10%. value = 0.001). There was a significant association between anti IgG seroprevalence and each of eosinophilia, total IgE and both combined. Anti IgG showed significant higher percentage in asthmatic children who recorded history of soil contact and pets contact as compared to control and pneumonic groups. IgG seropositivity was highly associated with fever, cough, wheezes and dyspnea with statistical significance. seropositivity has to be considered as a vital associated factor for asthmatic and pneumonic children, and eventually better to be considered in differential diagnosis by pediatricians. Further studies are still needed to explore the correlation between toxocariasis and different patient categories.
弓蛔虫病是一种未得到充分重视的土源性蠕虫感染，在幼虫移行时会出现呼吸道变化。本研究的目的是检测哮喘和肺炎患儿的血清阳性率，进而评估其与患儿临床表现、实验室检查结果及社会人口统计学危险因素之间的关联。共对50名哮喘患儿、50名肺炎患儿和50名健康对照者进行了粪便分析，采用直接涂片法和浓缩法以排除可能的交叉反应。采集血样进行全血细胞计数和嗜酸性粒细胞计数评估。检测血清中的抗IgG抗体，并测定总IgE水平。在所研究的患儿中，27.3%（41/150）检测到抗IgG。哮喘组的抗IgG水平显著高于对照组（26%，P值=0.033），肺炎组的抗IgG水平显著高于支气管哮喘组（46%，P值=0.030）和对照组（10%，P值=0.001）。抗IgG血清阳性率与嗜酸性粒细胞增多、总IgE以及两者合并情况均存在显著关联。与对照组和肺炎组相比，有土壤接触史和宠物接触史的哮喘患儿中抗IgG的百分比显著更高。IgG血清阳性与发热、咳嗽、喘息和呼吸困难高度相关，具有统计学意义。IgG血清阳性应被视为哮喘和肺炎患儿的一个重要相关因素，儿科医生在鉴别诊断中最好予以考虑。仍需进一步研究以探索弓蛔虫病与不同患者类别之间的相关性。
