血液学特征异常；及其与 COVID-19 感染的严重程度和结局的关系。
Haematological profile abnormalities; and its relationship with severity and outcome of COVID-19 infection.
机构信息
Department of Medicine, Rawalpindi Medical University and Allied Hospitals, Rawalpindi, Pakistan.
Department of Infectious Diseases, Rawalpindi Medical University and Allied Hospitals, Rawalpindi, Pakistan.
出版信息
Afr Health Sci. 2022 Sep;22(3):495-505. doi: 10.4314/ahs.v22i3.53.
BACKGROUND
Corona virus disease (Covid-19) caused by corona virus (SARS Cov-2) has affected millions of people around the world. Many diagnostic modalities have been tested but the blood complete picture remains the initial and most easily accessible investigation in Covid-19.
OBJECTIVES
The objective of this study was to find out the haematological abnormalities in relation to Covid-19 severity and outcome.
METHODS
This cross-sectional study was carried out from April 2020 to July 2020. One--hundred and fifty polymerase chain reaction (PCR) confirmed Covid-19 patients were inducted by random sampling. Haematological profile at admission was recorded. Data thus obtained was analyzed with respect to Covid-19 severity and outcome. The data was entered and analyzed using Statistical Package for Social Sciences (SPSS) version 19.
RESULTS
Out of a total of 150 patients included in the study, 77(51.3%) patients had mild disease at the time of admission, 42 (28%) had moderate disease while 31 (20.7%) had critical disease at the time of admission. Medians (interquartile range) of total leucocyte count (TLC), neutrophils, lymphocytes, neutrophils to lymphocytes ratio (NLR), platelets to lymphocytes ratio (PLR), neutrophils to monocyte ratio (NMR), monocyte to lymphocyte ratio (MLR) were 8.11 (IQR=4.88), 5.95 (IQR=4.58), 1.66 (IQR=1.10), 3.48 (IQR=4.20), 146.24 (IQR=130.75), 18.87 (IQR=14.07), 0.16 (IQR=0.13). Median NLR was higher in patients with critical illness 11.23 (IQR=10.70) as compared to those with stable 2.51 (IQR=1.77) and moderate 3.22 (IQR=3.60) disease (p< 0.000). Similarly TLC (p< 0.000), neutrophils (p< 0.000), lymphocytes (p< 0.000), NLR (p< 0.000), PLR (p< 0.000, p=0.001), MLR (p< 0.000), NMR (p< 0.000) had significant relationship with the severity and outcome of Covid-19 infection.
CONCLUSION
Many haematological parameters are significantly different and can be used to predict the severity and outcome of Covid-19 infection.
背景
由冠状病毒（SARS-CoV-2）引起的冠状病毒病（Covid-19）已影响到全球数百万人。已经测试了许多诊断方式，但全血细胞计数仍然是 Covid-19 的初始且最容易获得的检查。
目的
本研究的目的是找出与 Covid-19 严重程度和结局相关的血液学异常。
方法
这是一项 2020 年 4 月至 2020 年 7 月进行的横断面研究。通过随机抽样纳入了 150 例经聚合酶链反应（PCR）确诊的 Covid-19 患者。记录入院时的血液学特征。根据 Covid-19 的严重程度和结局分析获得的数据。使用社会科学统计软件包（SPSS）版本 19 输入和分析数据。
结果
在纳入研究的 150 例患者中，77 例（51.3%）患者在入院时患有轻度疾病，42 例（28%）患者患有中度疾病，31 例（20.7%）患者患有重症疾病。白细胞总数（TLC）、中性粒细胞、淋巴细胞、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、中性粒细胞与单核细胞比值（NMR）、单核细胞与淋巴细胞比值（MLR）中位数（四分位距）分别为 8.11（四分位距=4.88）、5.95（四分位距=4.58）、1.66（四分位距=1.10）、3.48（四分位距=4.20）、146.24（四分位距=130.75）、18.87（四分位距=14.07）、0.16（四分位距=0.13）。NLR 在患有危重病的患者中更高，为 11.23（四分位距=10.70），而在病情稳定的患者中为 2.51（四分位距=1.77），在中度疾病的患者中为 3.22（四分位距=3.60）（p<0.000）。同样，TLC（p<0.000）、中性粒细胞（p<0.000）、淋巴细胞（p<0.000）、NLR（p<0.000）、PLR（p<0.000，p=0.001）、MLR（p<0.000）、NMR（p<0.000）与 Covid-19 感染的严重程度和结局有显著关系。
结论
许多血液学参数差异显著，可用于预测 Covid-19 感染的严重程度和结局。
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