Department of Neurology, Hubei NO.3 People's Hospital of Jianghan University, 26 Zhongshan Road, Qiaokou District, Wuhan, China.
Department of Radiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
BMC Infect Dis. 2020 Jul 16;20(1):519. doi: 10.1186/s12879-020-05242-w.
Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan and has quickly spread across the world. The mortality rate in critically ill patients with COVID-19 is high. This study analyzed clinical and biochemical parameters between mild and severe patients, helping to identify severe or critical patients early.
In this single center, cross-sectional study, 143 patients were included and divided to mild/moderate and sever/critical groups. Correlation between the disease criticality and clinical features and peripheral blood biochemical markers was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve.
Significantly, disease severity was associated with age (r = 0.458, P < 0.001), comorbidities (r = 0.445, P < 0.001), white cell count (r = 0.229, P = 0.006), neutrophil count (r = 0.238, P = 0.004), lymphocyte count (r = - 0.295, P < 0.001), albumin (r = - 0.603, P < 0.001), high-density lipoprotein cholesterol (r = - 0.362, P < 0.001), serum potassium (r = - 0.237, P = 0.004), plasma glucose (r = 0.383, P < 0.001), total bilirubin (r = 0.340, P < 0.001), serum amyloid A (r = 0.58, P < 0.001), procalcitonin (r = 0.345, P < 0.001), C-reactive protein (r = 0.477, P < 0.001), lactate dehydrogenase (r = 0.548, P < 0.001), aspartate aminotransferase (r = 0.342, P < 0.001), alanine aminotransferase (r = 0.264, P = 0.001), erythrocyte sedimentation rate (r = 0.284, P = 0.001) and D-dimer (r = 0.477, P < 0.001) .
With the following parameters such as age > 52 years, C-reactive protein > 64.79 mg/L, lactate dehydrogenase > 245 U/L, D-dimer > 0.96 μg/mL, serum amyloid A > 100.02 mg/L, or albumin < 36 g/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Lymphocyte count, serum potassium, high-density lipoprotein cholesterol and procalcitonin may also be a prognostic indicator.
新型冠状病毒肺炎（COVID-19）是一种由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的新型传染病，起源于武汉，并迅速在全球范围内传播。COVID-19 重症患者的死亡率很高。本研究分析了轻症和重症患者的临床和生化参数，有助于早期识别重症或危重症患者。
在这项单中心、横断面研究中，纳入了 143 例患者，并将其分为轻症/中度组和重症/危重组。分析了疾病严重程度与临床特征和外周血生化标志物之间的相关性。通过 ROC 曲线推测危重症患者的截断值。
疾病严重程度与年龄（r=0.458，P<0.001）、合并症（r=0.445，P<0.001）、白细胞计数（r=0.229，P=0.006）、中性粒细胞计数（r=0.238，P=0.004）、淋巴细胞计数（r=-0.295，P<0.001）、白蛋白（r=-0.603，P<0.001）、高密度脂蛋白胆固醇（r=-0.362，P<0.001）、血清钾（r=-0.237，P=0.004）、血浆葡萄糖（r=0.383，P<0.001）、总胆红素（r=0.340，P<0.001）、血清淀粉样蛋白 A（r=0.58，P<0.001）、降钙素原（r=0.345，P<0.001）、C 反应蛋白（r=0.477，P<0.001）、乳酸脱氢酶（r=0.548，P<0.001）、天门冬氨酸氨基转移酶（r=0.342，P<0.001）、丙氨酸氨基转移酶（r=0.264，P=0.001）、红细胞沉降率（r=0.284，P=0.001）和 D-二聚体（r=0.477，P<0.001）显著相关。
年龄>52 岁、C 反应蛋白>64.79mg/L、乳酸脱氢酶>245U/L、D-二聚体>0.96μg/mL、血清淀粉样蛋白 A>100.02mg/L 或白蛋白<36g/L 时，COVID-19 进展为危重症应密切观察并可能预防。淋巴细胞计数、血清钾、高密度脂蛋白胆固醇和降钙素原也可能是预后指标。
