Guleroglu Filiz Yarsilikal, Ekmez Murat, Atas Busra Seker, Cetin Ali
Department of Obstetrics and Gynecology, Health Sciences University, Haseki Training and Research Hospital, Istanbul, Turkiye.
North Clin Istanb. 2023 Feb 8;10(1):40-47. doi: 10.14744/nci.2022.94752. eCollection 2023.
This study was conducted to elucidate the predictive value of hematological indices, the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV), to determine the clinical outcome of placental abruption in women regarding stillbirth.
This retrospective review of medical charts was performed in a tertiary center experienced for maternal, fetal, and neonatal care, including 89 pregnant women with placental abruption with or without stillbirth. The results of the hemogram tests with hematological indices, including the NLR, PLR, and MPV, which are the routinely obtained parameters both at admission and 4 h postoperatively, were correlated with other clinical parameters.
The findings showed that although there were remarkable changes in some of the clinical features of women with placental abruption with or without stillbirth, in general, the study groups were found comparable regarding these variables. The values of NLR, PLR, and MPV in women with stillbirth presented remarkable changes when hemogram tests were used as pre-operative and post-operative laboratory examinations, although these changes did not correlate with each other meaningfully.
Stillbirth is one of the most important complications of placental abruption requiring rapid diagnosis and regular follow-up after its surgical management. To fine-tune emergent management of placental abruption in women with stillbirth, the indices of NLR, PLR, and MPV calculated at the first admission as well as during follow-up of the patients have clinical value as easily obtainable laboratory findings like other hematological parameters.
本研究旨在阐明血液学指标，即中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）及平均血小板体积（MPV）的预测价值，以确定胎盘早剥女性死产的临床结局。
在一家具备孕产妇、胎儿及新生儿护理经验的三级中心，对病历进行回顾性分析，纳入89例有或无死产的胎盘早剥孕妇。血常规检查结果中的血液学指标，包括NLR、PLR及MPV，这些指标在入院时及术后4小时均为常规获取参数，并与其他临床参数进行关联分析。
研究结果表明，尽管有或无死产的胎盘早剥女性的某些临床特征存在显著变化，但总体而言，这些研究组在这些变量方面具有可比性。当将血常规检查用作术前和术后实验室检查时，死产女性的NLR、PLR及MPV值出现了显著变化，尽管这些变化之间并无有意义的关联。
死产是胎盘早剥最重要的并发症之一，手术处理后需要快速诊断及定期随访。为优化死产女性胎盘早剥的紧急处理，患者首次入院时及随访期间计算的NLR、PLR及MPV指标，作为易于获取的实验室检查结果，与其他血液学参数一样具有临床价值。
