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Brain aging, epigenetic changes, tau and neurodegeneration.

作者信息

Avila Jesús

机构信息

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), 28049 Madrid, Spain.

Network Centre for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain.

出版信息

Aging Brain. 2021 Feb 15;1:100004. doi: 10.1016/j.nbas.2020.100004. eCollection 2021.

DOI:10.1016/j.nbas.2020.100004
PMID:36911519
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9997149/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/9997149/11ff432ca4c3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/9997149/11ff432ca4c3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8eb/9997149/11ff432ca4c3/gr1.jpg

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本文引用的文献

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In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.体内重编程改善齿状回细胞的衰老特征,并改善小鼠的记忆。
Stem Cell Reports. 2020 Nov 10;15(5):1056-1066. doi: 10.1016/j.stemcr.2020.09.010. Epub 2020 Oct 22.
2
Synergy between amyloid-β and tau in Alzheimer's disease.淀粉样蛋白-β与tau 在阿尔茨海默病中的协同作用。
Nat Neurosci. 2020 Oct;23(10):1183-1193. doi: 10.1038/s41593-020-0687-6. Epub 2020 Aug 10.
3
Retrotransposon activation by distressed mitochondria in neurons.神经元中受损线粒体导致反转录转座子的激活。
Biochem Biophys Res Commun. 2020 May 7;525(3):570-575. doi: 10.1016/j.bbrc.2020.02.106. Epub 2020 Feb 27.
4
Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age.淀粉样蛋白和 tau 成像生物标志物解释从中年后期开始的认知能力下降。
Brain. 2020 Jan 1;143(1):320-335. doi: 10.1093/brain/awz378.
5
Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease.淀粉样β蛋白和 Tau 蛋白协同作用导致阿尔茨海默病模型中可逆的行为和转录缺陷。
Cell Rep. 2019 Dec 10;29(11):3592-3604.e5. doi: 10.1016/j.celrep.2019.11.044.
6
Enhanced Tau Protein Translation by Hyper-Excitation.通过过度兴奋增强tau蛋白翻译
Front Aging Neurosci. 2019 Nov 20;11:322. doi: 10.3389/fnagi.2019.00322. eCollection 2019.
7
Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation.小胶质细胞和外周巨噬细胞表型在发育和神经炎症中的趋同。
J Neurosci. 2020 Jan 22;40(4):784-795. doi: 10.1523/JNEUROSCI.1523-19.2019. Epub 2019 Dec 9.
8
Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity.裸鼹鼠的单细胞转录组学揭示了哺乳动物免疫的意外特征。
PLoS Biol. 2019 Nov 21;17(11):e3000528. doi: 10.1371/journal.pbio.3000528. eCollection 2019 Nov.
9
Editing the Epigenome to Tackle Brain Disorders.编辑表观基因组以应对脑部疾病。
Trends Neurosci. 2019 Dec;42(12):861-870. doi: 10.1016/j.tins.2019.10.003. Epub 2019 Nov 7.
10
NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.NLRP3 炎性小体抑制可延长雄性小鼠寿命并预防心脏衰老。
Aging Cell. 2020 Jan;19(1):e13050. doi: 10.1111/acel.13050. Epub 2019 Oct 18.