Song Yingcai, Qian Xiaozhe, Du Weijia
Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Thoracic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Front Surg. 2023 Feb 23;10:1093969. doi: 10.3389/fsurg.2023.1093969. eCollection 2023.
Calcium channel blockers and magnesium sulfate are frequently used together, particularly in women with underlying chronic hypertension and pre-eclampsia. A review of the literature showed prolonged neuromuscular blockade after treatment with magnesium sulfate. Since magnesium and calcium have opposite effects on the neuromuscular junctions, muscle weakness may become a postoperative manifestation of magnesium sulfate and calcium antagonist treatment in the obstetric population; however, limited information is available regarding this postulation. Here, we report a case wherein rocuronium activity was markedly prolonged due to pretreatment with magnesium sulfate and nicardipine after general anesthesia during an emergency cesarean delivery.
钙通道阻滞剂和硫酸镁经常联合使用，尤其是在患有潜在慢性高血压和先兆子痫的女性中。文献综述显示，硫酸镁治疗后神经肌肉阻滞时间延长。由于镁和钙对神经肌肉接头有相反的作用，肌肉无力可能成为产科人群中硫酸镁和钙拮抗剂治疗后的术后表现；然而，关于这一假设的信息有限。在此，我们报告一例在急诊剖宫产全身麻醉期间，因术前使用硫酸镁和尼卡地平，罗库溴铵的作用时间显著延长的病例。
