Department of Otorhinolaryngology - Head and Neck Surgery, Head, Neck and Thyroid Oncology Unit.
Department of Endocrinology and Thyroid Oncology Unit, Guy's and St Thomas NHS Foundation Trust, London, UK.
Curr Opin Otolaryngol Head Neck Surg. 2023 Apr 1;31(2):83-88. doi: 10.1097/MOO.0000000000000875.
To highlight recent advances in our understanding of the epidemiology, incidence, evaluation, management and outcomes of primary thyroid lymphoma (PTL), and highlight the indications and limitations of surgery.
The differential diagnosis of a rapidly enlarging thyroid mass with or without obstructive symptoms should include PTL and anaplastic thyroid cancer. When PTL is suspected, initial investigations should include blood tests and ultrasound-guided biopsy preferably core need biopsy to allow tissue typing and immunohistochemistry analysis. Systemic imaging with FDG PET-CT is required for staging. Surgery is not recommended for treatment purposes and should be reserved for diagnosis and airway management. Treatment includes chemotherapy and radiotherapy and offer an excellent prognosis.
PTL is a rare malignancy making diagnosis and management challenging. Initial investigations of suspected PTL should include blood tests and ultrasound-guided biopsy, preferably core needle biopsy and systemic imaging is required for staging. Surgery is reserved for diagnosis and airway management. Chemotherapy and radiotherapy are the treatment of choice.
强调我们对原发性甲状腺淋巴瘤（PTL）的流行病学、发病率、评估、管理和结局的理解的最新进展，并强调手术的适应证和局限性。
对于伴有或不伴有阻塞症状的迅速增大的甲状腺肿块，鉴别诊断应包括 PTL 和间变性甲状腺癌。当怀疑 PTL 时，初始检查应包括血液检查和超声引导下活检，最好是核心针活检，以允许组织分型和免疫组织化学分析。FDG PET-CT 全身成像用于分期。手术不建议用于治疗目的，应保留用于诊断和气道管理。治疗包括化疗和放疗，预后良好。
PTL 是一种罕见的恶性肿瘤，其诊断和治疗具有挑战性。疑似 PTL 的初始检查应包括血液检查和超声引导下活检，最好是核心针活检，全身成像用于分期。手术保留用于诊断和气道管理。化疗和放疗是首选的治疗方法。
