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胶囊增加了肺炎克雷伯菌对最后手段多黏菌素的易感性，但对其他抗生素没有影响。

The Capsule Increases Susceptibility to Last-Resort Polymyxins, but Not to Other Antibiotics, in Klebsiella pneumoniae.

机构信息

Institut Pasteur, Université Paris Cité, CNRS UMR3525, Microbial Evolutionary Genomics, Paris, France.

出版信息

Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0012723. doi: 10.1128/aac.00127-23. Epub 2023 Mar 13.

DOI:10.1128/aac.00127-23
PMID:36912665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10112221/
Abstract

The extracellular capsule is a virulence factor present in many facultative pathogens, but its role in antimicrobial resistance remains controversial. To shed light on this debate, we tested six antibiotics on four Klebsiella pneumoniae species complex strains. Noncapsulated strains exhibited increased tolerance to polymyxins, but not to other antibiotics, as measured using the MIC. Our results urge caution on the use of therapeutic agents that target the capsule and may result in selection for its inactivation.

摘要

细胞外囊是许多兼性病原体的毒力因子，但它在抗微生物药物耐药性中的作用仍存在争议。为了阐明这一争论，我们测试了六种抗生素对四种肺炎克雷伯菌属种复合菌株的作用。非荚膜菌株对多黏菌素的耐药性增加，但对其他抗生素则不然，这一点可通过 MIC 来衡量。我们的结果告诫人们要谨慎使用以荚膜为靶点的治疗药物，因为这可能会导致荚膜失活的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa06/10112221/92ff046a15fb/aac.00127-23-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa06/10112221/92ff046a15fb/aac.00127-23-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa06/10112221/92ff046a15fb/aac.00127-23-f001.jpg

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