婴儿期摄入蛋类与女性青春期早期较低的脂肪质量指数相关。
Egg Introduction during Infancy is Associated with Lower Fat Mass Index in Females at Early Adolescence.
机构信息
Division of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA; Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY, USA.
Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY, USA.
出版信息
J Nutr. 2023 Jan;153(1):158-166. doi: 10.1016/j.tjnut.2022.11.003. Epub 2022 Dec 20.
BACKGROUND
Egg consumption may play an important role in early-life growth given their high-quality protein, essential fatty acids, and micronutrients.
OBJECTIVES
Study objectives were to examine the longitudinal associations of infant age at egg introduction with obesity outcomes in early childhood, middle childhood (mid-childhood), and early adolescence.
METHODS
We used existing data from 1089 mother-child dyads from Project Viva to estimate age at egg introduction through a questionnaire completed by mothers at ∼1 y postpartum (mean ± SD, 13.3 ± 1.2 mo). Outcome measures included height and weight (early childhood, mid-childhood, and early adolescence), body composition including total fat mass, trunk fat mass, and lean mass (mid-childhood and early adolescence), and plasma adiponectin and leptin (early and mid-childhood and early adolescence). We defined childhood obesity as sex- and age-specific BMI ≥ 95th percentile. We estimated the associations of infant age at egg introduction with risk of obesity using multivariable logistic regression and multivariable linear regression models for BMI-z-score, body composition measures, and adiposity hormones; adjusted for maternal prepregnancy BMI and sociodemographics.
RESULTS
Among females, those introduced to egg by the 1-y survey had a lower total fat mass index (confounder-adjusted mean difference, -1.23 kg/m; 95% CI: -2.14, -0.31), and trunk fat mass index (confounder-adjusted mean difference, -0.57 kg/m; 95% CI: -1.01, -0.12) in early adolescence compared to those not introduced (reference group). However, no associations between infant age at egg introduction and risk of obesity were observed among males (confounder-adjusted odd ratio [aOR], 1.97; 95% CI: 0.90, 4.30) or females (aOR, 0.68; 95% CI: 0.38, 1.24) across all ages. Egg introduction in infancy was associated with lower plasma adiponectin among females (confounder-adjusted mean difference, -1.93 μg/mL; 95% CI: -3.70, -0.16) in early childhood only.
CONCLUSIONS
Egg introduction during infancy among females is associated with lower total fat mass index in early adolescence and plasma adiponectin in early childhood. This trial was registered at clinicaltrials.gov as NCT02820402.
背景
鉴于鸡蛋富含高质量蛋白质、必需脂肪酸和微量元素，其在婴儿成长早期可能发挥着重要作用。
目的
本研究旨在探究婴儿开始食用鸡蛋的年龄与儿童早期、中期和青春期早期肥胖结局之间的纵向关联。
方法
我们利用 Viva 项目中 1089 对母婴对子的数据，通过母亲在产后约 1 年时（平均±标准差，13.3±1.2 个月）完成的问卷来估计开始食用鸡蛋的年龄。结局指标包括身高和体重（儿童早期、中期和青春期早期）、身体成分（包括总脂肪量、躯干脂肪量和瘦体重）和血浆脂联素和瘦素（儿童早期和中期以及青春期早期）。我们将儿童肥胖定义为性别和年龄特异性 BMI≥第 95 百分位数。我们使用多变量逻辑回归和多变量线性回归模型，根据婴儿开始食用鸡蛋的年龄来估计肥胖风险，模型中调整了母亲的孕前 BMI 和社会人口统计学特征。
结果
在女性中，与未开始食用鸡蛋的女性（参照组）相比，在 1 岁时开始食用鸡蛋的女性在青春期早期的总脂肪量指数（经混杂因素调整的平均差值，-1.23kg/m；95%CI：-2.14，-0.31）和躯干脂肪量指数（经混杂因素调整的平均差值，-0.57kg/m；95%CI：-1.01，-0.12）更低。然而，在男性（经混杂因素调整的比值比[aOR]，1.97；95%CI：0.90，4.30）或女性（aOR，0.68；95%CI：0.38，1.24）中，均未观察到婴儿开始食用鸡蛋的年龄与肥胖风险之间存在关联。在女性中，婴儿开始食用鸡蛋仅与儿童早期较低的血浆脂联素水平相关（经混杂因素调整的平均差值，-1.93μg/mL；95%CI：-3.70，-0.16）。
结论
在女性中，婴儿期开始食用鸡蛋与青春期早期的总脂肪量指数较低和儿童早期的血浆脂联素水平较低有关。本试验在 clinicaltrials.gov 注册，编号为 NCT02820402。
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