Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Am J Clin Nutr. 2021 Jul 1;114(1):117-123. doi: 10.1093/ajcn/nqab043.
Excessive abdominal adiposity is associated with health risks in children and adults. Higher consumption of fruit juice and other sources of fructose has been shown to promote weight gain and specifically visceral adiposity in adulthood.
We aimed to examine the longitudinal associations of fruit juice intake in infancy with visceral adiposity in mid-childhood and early adolescence.
We analyzed data from 783 participants in Project Viva, a US prebirth cohort. Our exposure was fruit juice intake at 1 y old. We measured visceral adipose tissue (VAT), subcutaneous abdominal adipose tissue (SAAT), and total abdominal adipose tissue (TAAT) in mid-childhood (mean age 7.8 ± 0.7 y) and early adolescence (13 ± 0.8 y) using DXA. We examined longitudinal associations of fruit juice intake at 1 y with VAT, SAAT, and TAAT area sex-specific standard deviation scores (SDSs) in mid-childhood and early adolescence using linear mixed models. We adjusted for child age at outcome, sex, race/ethnicity, age and BMI z-score at 1 y-questionnaire, maternal prepregnancy BMI, level of education, and prenatal sugar-sweetened beverage intake, paternal BMI, and median household income at birth.
After adjusting for child and parental covariates, each serving (120 mL) per day of fruit juice intake at 1 y was associated with persistently greater VAT area SDS (β = 0.08; 95% CI: 0.03, 0.13) at both timepoints in boys and girls. The association of fruit juice intake with VAT appeared stronger than that with SAAT (β = 0.05; 95% CI: 0.00, 0.09) and TAAT (β = 0.05; 95% CI: 0.01, 0.10).
Higher fruit juice intake in infancy was associated with greater abdominal adiposity, particularly VAT, in mid-childhood and early adolescence. Our findings support limiting fruit juice intake in infancy, which can have later impact on visceral adiposity in childhood and adolescence.Clinical Trial Registry number: NCT02820402 (https://clinicaltrials.gov/ct2/show/NCT02820402).
过多的腹部肥胖与儿童和成人的健康风险有关。较高的果汁和其他果糖来源的摄入量已被证明会导致成年后体重增加，特别是内脏脂肪增加。
我们旨在研究婴儿期果汁摄入量与儿童中期和青少年早期内脏脂肪堆积的纵向关联。
我们分析了来自美国孕前队列项目 Viva 的 783 名参与者的数据。我们的暴露因素是 1 岁时的果汁摄入量。我们使用 DXA 测量了儿童中期（平均年龄 7.8±0.7 岁）和青少年早期（13±0.8 岁）的内脏脂肪组织（VAT）、腹部皮下脂肪组织（SAAT）和腹部总脂肪组织（TAAT）。我们使用线性混合模型，在儿童中期和青少年早期，根据果汁摄入量与 VAT、SAAT 和 TAAT 面积性别特异性标准偏差分数（SDS）的纵向关联，对儿童年龄、性别、种族/民族、1 岁时问卷的年龄和 BMI z 分数、母亲孕前 BMI、教育水平和产前含糖饮料摄入量、父亲 BMI 和出生时的家庭中位数收入进行了调整。
在调整了儿童和父母的混杂因素后，1 岁时每天每增加一份（120 毫升）果汁摄入与男孩和女孩在两个时间点的 VAT 面积 SDS 持续增加相关（β=0.08；95%CI：0.03，0.13）。与果汁摄入量与 VAT 的关联似乎强于与 SAAT（β=0.05；95%CI：0.00，0.09）和 TAAT（β=0.05；95%CI：0.01，0.10）的关联。
婴儿期较高的果汁摄入量与儿童中期和青少年早期的腹部脂肪堆积，特别是内脏脂肪堆积有关。我们的研究结果支持限制婴儿期果汁摄入量，这可能对儿童和青少年期的内脏脂肪堆积产生后续影响。临床试验注册号：NCT02820402（https://clinicaltrials.gov/ct2/show/NCT02820402）。
