Elsenhans B, Schmolke G, Kolb K, Stokes J, Forth W
Walther-Straub-Institut für Pharmakologie und Toxikologie, Medizinische Fakultät der Ludwig-Maximilians-Universität München, Federal Republic of Germany.
Ecotoxicol Environ Saf. 1987 Dec;14(3):275-87. doi: 10.1016/0147-6513(87)90071-6.
Exposure to toxic and essential metals is thought to be reflected by corresponding metal concentrations in tissues. However, toxic and essential metals may influence each other in regard to their retention in the body. Therefore a basic diet containing four toxic metals (As 7, Cd 9, Ni 13, and Pb 20 ppm) and adequate amounts of essential metals was fed to rats for 2 weeks. Test groups received the basic diet with increasing concentrations of one of the toxic metals (up to 90 ppm As, 180 ppm Cd, 365 ppm Ni, and 394 ppm Pb). As, Cd, Ni, Pb, Cu, Fe, Mn, and Zn were determined by atomic emission spectroscopy in liver, kidney, intestine, brain, muscle, bone, skin, hair, and blood. A linear relationship between diet and tissue concentration is observed for As and Ni in the kidney, for Cd in the liver, and for Pb in the bone. In other tissues saturation was observed. While Cd-Fe interactions were common to most of the tissues, other interactions were detected only in specific tissues, e.g., As-Cu in the kidney, Cd-Zn in the liver, and As-Mn, Cd-Mn, or Ni-Cu in the intestine. Increases of renal Pb and intestinal Cd by dietary Ni, and a decrease in bone As by dietary Pb were the most pronounced interactions between the toxic metals. The results demonstrate that potential target organs for the evaluation of metal exposure need to be carefully analyzed for interfering metal-metal interactions.
接触有毒金属和必需金属被认为可通过组织中相应的金属浓度来反映。然而，有毒金属和必需金属在体内的潴留方面可能会相互影响。因此，给大鼠喂食一种含有四种有毒金属（砷7 ppm、镉9 ppm、镍13 ppm和铅20 ppm）以及适量必需金属的基础饮食，持续2周。试验组接受添加了一种有毒金属浓度递增（最高达90 ppm砷、180 ppm镉、365 ppm镍和394 ppm铅）的基础饮食。通过原子发射光谱法测定肝脏、肾脏、肠道、大脑、肌肉、骨骼、皮肤、毛发和血液中的砷、镉、镍、铅、铜、铁、锰和锌。在肾脏中，砷和镍、在肝脏中镉、在骨骼中铅的饮食与组织浓度之间观察到线性关系。在其他组织中则观察到饱和现象。虽然镉与铁的相互作用在大多数组织中都很常见，但其他相互作用仅在特定组织中被检测到，例如在肾脏中砷与铜、在肝脏中镉与锌、在肠道中砷与锰、镉与锰或镍与铜。饮食中的镍使肾脏中铅含量增加以及肠道中镉含量增加，饮食中的铅使骨骼中砷含量降低，这些是有毒金属之间最显著的相互作用。结果表明，对于评估金属暴露的潜在靶器官，需要仔细分析其是否存在干扰性的金属 - 金属相互作用。
