A robust cascaded deep neural network for image reconstruction of single plane wave ultrasound RF data.

Reconstruction of ultrasound data from single plane wave Radio Frequency (RF) data is a challenging task. The traditional Delay and Sum (DAS) method produces an image with low resolution and contrast, if employed with RF data from only a single plane wave. A Coherent Compounding (CC) method that reconstructs the image by coherently summing the individual DAS images was proposed to enhance the image quality. However, CC relies on a large number of plane waves to accurately sum the individual DAS images, hence it produces high quality images but with low frame rate that may not be suitable for time-demanding applications. Therefore, there is a need for a method that can create a high quality image with higher frame rates. Furthermore, the method needs to be robust against the input transmission angle of the plane wave. To reduce the method's dependence on the input angle, we propose to unify the RF data at different angles by learning a linear data transformation from different angled data to a common, 0° data. We further propose a cascade of two independent neural networks to reconstruct an image, similar in quality to CC, by making use of a single plane wave. The first network, denoted as "PixelNet", is a fully Convolutional Neural Network (CNN) which takes in the transformed time-delayed RF data as input. PixelNet learns optimal pixel weights that get element-wise multiplied with the single angle DAS image. The second network is a conditional Generative Adversarial Network (cGAN) which is used to further enhance the image quality. Our networks were trained on the publicly available PICMUS and CPWC datasets and evaluated on a completely separate, CUBDL dataset obtained from different acquisition settings than the training dataset. The results thus obtained on the testing dataset, demonstrate the networks' ability to generalize well on unseen data, with frame rates better than the CC method. This paves the way for applications that require high-quality images reconstructed at higher frame rates.