生化检测在生殖流行病学研究中的应用。
The use of biochemical assays in epidemiologic studies of reproduction.
作者信息
Wilcox A J, Baird D D, Weinberg C R, Armstrong E G, Musey P I, Wehmann R E, Canfield R E
机构信息
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
出版信息
Environ Health Perspect. 1987 Nov;75:29-35. doi: 10.1289/ehp.877529.
Recent progress in the assay of urinary hormones has opened new opportunities for epidemiologists to study hormones and health outcomes. This is especially true for studies of female reproduction. The cyclic nature of female reproduction can be fully described only by continuous frequent measurements that, in order to be practical, require easily collected biological specimens. We describe our experience in collecting and analyzing daily urine specimens from 301 healthy women. We conclude that this approach is not only feasible but potentially of great value to epidemiologists for studying fertility, early pregnancy, the effects of toxic exposures on reproduction, and the relationships between reproduction and later risk of chronic diseases.
尿激素检测的最新进展为流行病学家研究激素与健康结果开辟了新机遇。这在女性生殖研究中尤为如此。女性生殖的周期性特征只有通过持续频繁的测量才能得到全面描述，而为了具有实际可行性，这些测量需要易于采集的生物标本。我们描述了从301名健康女性中收集和分析每日尿液标本的经验。我们得出结论，这种方法不仅可行，而且对于流行病学家研究生育能力、早期妊娠、有毒暴露对生殖的影响以及生殖与后期慢性病风险之间的关系可能具有巨大价值。
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