红细胞原卟啉与血铅的剂量反应曲线：铁状态的影响。

Dose-response curves for erythrocyte protoporphyrin vs blood lead: effects of iron status.

作者信息

Marcus A H, Schwartz J

机构信息

U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.

出版信息

Environ Res. 1987 Dec;44(2):221-7. doi: 10.1016/s0013-9351(87)80230-x.

DOI:10.1016/s0013-9351(87)80230-x

PMID:3691443

Abstract

An increase in erythrocyte protoporphyrin (EP) is one of the most useful indicators of adverse biological response to lead exposure. A nonlinear mathematical model relating EP to blood lead concentration (PbB) was fitted to data in a sample of 1677 U.S. children (ages 2-6 years) in the Second National Health and Nutrition Examination Survey (NHANES II). Iron status was defined by percentage transferrin saturation (PTS). The dose-response curves for EP vs PbB increased systematically with decreasing PTS, largely due to decrease of a parameter proportional to red cell lead-holding capacity with decreasing PTS.

摘要

红细胞原卟啉（EP）增加是铅暴露不良生物学反应最有用的指标之一。在第二次全国健康与营养检查调查（NHANES II）中，将一个把EP与血铅浓度（PbB）相关联的非线性数学模型应用于1677名美国儿童（2至6岁）样本的数据。铁状态由转铁蛋白饱和度百分比（PTS）定义。随着PTS降低，EP与PbB的剂量反应曲线系统性上升，这主要是由于随着PTS降低，与红细胞铅容纳能力成比例的一个参数下降所致。