将生物医学肌肉组织工程再用于细胞农业：挑战与机遇。
Repurposing biomedical muscle tissue engineering for cellular agriculture: challenges and opportunities.
机构信息
Department of Biomedical Engineering, University of Connecticut, Farmington, CT, USA.
Department of Biomedical Engineering, University of Connecticut, Farmington, CT, USA.
出版信息
Trends Biotechnol. 2023 Jul;41(7):887-906. doi: 10.1016/j.tibtech.2023.02.002. Epub 2023 Mar 11.
Cellular agriculture is an emerging field rooted in engineering meat-mimicking cell-laden structures using tissue engineering practices that have been developed for biomedical applications, including regenerative medicine. Research and industrial efforts are focused on reducing the cost and improving the throughput of cultivated meat (CM) production using these conventional practices. Due to key differences in the goals of muscle tissue engineering for biomedical versus food applications, conventional strategies may not be economically and technologically viable or socially acceptable. In this review, these two fields are critically compared, and the limitations of biomedical tissue engineering practices in achieving the important requirements of food production are discussed. Additionally, the possible solutions and the most promising biomanufacturing strategies for cellular agriculture are highlighted.
细胞农业是一个新兴领域，其基础是使用组织工程实践来构建模拟肉类的细胞结构，这些实践已经为生物医学应用（包括再生医学）所开发。研究和工业界的重点是通过这些传统实践来降低培养肉（CM）生产的成本并提高产量。由于生物医学和食品应用的肌肉组织工程目标存在关键差异，因此传统策略在经济和技术上可能不可行或在社会上不可接受。在这篇综述中，对这两个领域进行了批判性比较，并讨论了生物医学组织工程实践在实现食品生产的重要要求方面的局限性。此外，还强调了细胞农业的可能解决方案和最有前途的生物制造策略。
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