Department of Otorhinolaryngology, University of Pennsylvania.
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA.
J Craniofac Surg. 2023 May 1;34(3):e326-e329. doi: 10.1097/SCS.0000000000009258. Epub 2023 Mar 14.
To assess existing literature on topical intranasal fluorescein (TINF) for the diagnosis and localization of nasal cerebrospinal fluid (CSF).
Systematic review.
A 6-database literature search was conducted to identify articles providing insight into TINF for the diagnosis and treatment of sinonasal CSF leak. Demographic characteristics, technical details, efficacy, and safety data were extracted and analyzed. Methodological quality was assessed using Methodological Items for Non-Randomized Studies (MINORS) criteria.
All studies reported a diagnostic accuracy rate ≥96%. There were no major complications reported for any patient (n=99) with either 5% or 10% fluorescein use. The MINORS instrument of methodological quality indicated that the assessed studies were of moderate quality (7.29 out of a maximum score of 24).
This systematic review indicates that TINF is an easy, safe, inexpensive, and sensitive approach for the diagnosis and treatment of sinonasal CSF leakage. For these reasons, it may be especially well suited for resource-limited clinical scenarios.
评估现有关于鼻内局部荧光素（TINF）在诊断和定位鼻脑脊液（CSF）中的应用文献。
系统评价。
进行了 6 个数据库的文献检索，以确定提供有关 TINF 用于诊断和治疗鼻鼻窦 CSF 漏的文章。提取并分析了人口统计学特征、技术细节、疗效和安全性数据。使用非随机研究方法学项目（MINORS）标准评估方法学质量。
所有研究报告的诊断准确率均≥96%。使用 5%或 10%荧光素的 99 名患者均未报告任何重大并发症。方法学质量的 MINORS 仪器表明，评估的研究为中等质量（24 分中的 7.29 分）。
本系统评价表明，TINF 是一种用于诊断和治疗鼻鼻窦 CSF 漏的简便、安全、经济且敏感的方法。由于这些原因，它可能特别适合资源有限的临床情况。
