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高强度聚焦超声消融治疗腹直肌子宫内膜异位症的疗效及安全性:一项7年随访的临床研究

Efficacy and safety of high-intensity focused ultrasound ablation for rectus abdominis endometriosis: a 7-year follow-up clinical study.

作者信息

Yang Qinghua, Zhang Xiaoying

机构信息

Senior Department of Ophthalmology, the Third Medical Center of PLA General Hospital, Beijing, China.

Department of Ultrasonography, Chongqing All Cure Cancer Hospital, Chongqing, China.

出版信息

Quant Imaging Med Surg. 2023 Mar 1;13(3):1417-1425. doi: 10.21037/qims-22-695. Epub 2023 Jan 29.

Abstract

BACKGROUND

The aim of this study was to evaluate the efficacy and safety of high-intensity focused ultrasound (HIFU) for the ablation of rectus abdominis endometriosis (RAE) as a noninvasive modality.

METHODS

All patients diagnosed with RAE who underwent HIFU ablation were followed up for 7 years. The following demographic characteristics of the patients were collected and analyzed: lesion location, size, and number; HIFU ablation; and recurrence.

RESULTS

HIFU ablated 65 lesions in 56 patients with a median age of 36.5±9.19 years and a median lesion volume of 8.2 cm. The main symptom was a palpable painful mass (n=61, 93.9%), which protruded from the skin surface in 6 cases (9.23%). Ultrasound was initially scanned in all patients (n=56, 100%), while 6% (n=3) required magnetic resonance imaging (MRI) to distinguish the features and range of the masses. Ablation was completed with a median sonication time of 393 s, a treatment time of 46 min, 150 W of power, and 63,525 J of total energy to treat lesions with a median volume of 5.03 cm. There were no severe complications during the 84-month follow-up period, except for 2 patients who experiences hematuria. The pooled recurrence rate of RAE in this cohort was 1.8% (n=1).

CONCLUSIONS

As HIFU is effective and safe and retains the integrity of the abdominal wall, it should be the preferred method for the treatment of RAE.

摘要

背景

本研究旨在评估高强度聚焦超声(HIFU)作为一种非侵入性方式消融腹直肌子宫内膜异位症(RAE)的疗效和安全性。

方法

对所有接受HIFU消融治疗的RAE患者进行了7年的随访。收集并分析了患者的以下人口统计学特征:病变位置、大小和数量;HIFU消融情况;以及复发情况。

结果

HIFU消融了56例患者的65个病灶,患者中位年龄为36.5±9.19岁,中位病灶体积为8.2cm。主要症状为可触及的疼痛性肿块(n=61,93.9%),其中6例(9.23%)肿块突出于皮肤表面。所有患者(n=56,100%)均首先进行了超声检查,而6%(n=3)的患者需要磁共振成像(MRI)来区分肿块的特征和范围。消融完成时,中位超声照射时间为393秒,治疗时间为46分钟,功率为150瓦,总能量为63525焦耳,用于治疗中位体积为5.03cm的病灶。在84个月的随访期内,除2例患者出现血尿外,未发生严重并发症。该队列中RAE的汇总复发率为1.8%(n=1)。

结论

由于HIFU有效且安全,并保留了腹壁的完整性,因此应成为治疗RAE的首选方法。

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