Shi Jinyao, Wu Zhouqiao, Wu Xiaolong, Huangfu Longtao, Guo Ting, Cheng Xiaojing, Han Jing, Li Ziyu, Xing Xiaofang, Ji Jiafu
Department of Gastrointestinal Translational Research, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
iScience. 2023 Feb 16;26(3):106214. doi: 10.1016/j.isci.2023.106214. eCollection 2023 Mar 17.
Recent evidence demonstrates that the reprogramming of energy metabolism can interact with the tumor immune microenvironment, thereby participating in the progression of cancer. In this study, multi-omics data of 2471 gastric cancer samples were used to identify tumor glycometabolism and its correlation with tumor immune microenvironment. A series of bioinformatic approaches were performed to establish a scoring system to predict the survival and response of chemotherapy and immunotherapy. Three glycometabolic subtypes and two immune clustering subgroups of gastric cancer were determined. We further established a Gluco-Immune Scoring system to quantify the cancer glycometabolic status and immune infiltration of individual patients. Patients with low Gluco-Immune Score were sensitive to adjuvant chemotherapy, while patients with high Gluco-Immune Score may benefit from immunotherapy. Our results indicate that in gastric cancer, the assessment of tumor glucose metabolism and immune microenvironment has application value for the prediction of curative effects and the formulation of combined treatment strategies.
近期证据表明，能量代谢重编程可与肿瘤免疫微环境相互作用，从而参与癌症进展。在本研究中，利用2471例胃癌样本的多组学数据来识别肿瘤糖代谢及其与肿瘤免疫微环境的相关性。采用了一系列生物信息学方法建立评分系统，以预测化疗和免疫治疗的生存情况及反应。确定了胃癌的三种糖代谢亚型和两个免疫聚类亚组。我们进一步建立了糖代谢-免疫评分系统，以量化个体患者的癌症糖代谢状态和免疫浸润情况。糖代谢-免疫评分低的患者对辅助化疗敏感，而糖代谢-免疫评分高的患者可能从免疫治疗中获益。我们的结果表明，在胃癌中，评估肿瘤葡萄糖代谢和免疫微环境对疗效预测及联合治疗策略的制定具有应用价值。
