Rujkorakarn Ploysai, Margolis Michael J, Morvey Diana, Zhou Yujia, Foster C Stephen
Massachusetts Eye Research and Surgery Institution, Waltham, MA, USA.
The Ocular Immunology and Uveitis Foundation, Waltham, MA, USA.
Clin Ophthalmol. 2023 Mar 7;17:749-755. doi: 10.2147/OPTH.S404826. eCollection 2023.
To assess the possible correlation of anti-retinal antibody titers and number of anti-retinal antibodies with outcome measurements including visual acuity, subjective vision loss, visual field, and electroretinography in patients with autoimmune retinopathy.
Single-center, retrospective cross-sectional study.
Patients with autoimmune retinopathy who underwent anti-retinal antibody testing at least twice during their follow-up were enrolled. Anti-retinal antibody titers and numbers were grouped as improved, stable, or worsened. Outcomes included Snellen visual acuity, patient-reported vision loss, Humphrey visual field mean deviations, and electroretinography parameters.
Thirty-one eyes among 16 patients with autoimmune retinopathy were included. Between-group analyses of visual acuity, subjective vision loss, visual field, and electroretinography outcomes did not reveal any significant differences by anti-retinal antibody titer or number group at a 95% confidence interval.
Changes in anti-retinal antibody titers or numbers were not associated with any vision outcome. Repeated anti-retinal antibody testing may be unnecessary after diagnosis of autoimmune retinopathy and detection of an anti-retinal antibody.
评估自身免疫性视网膜病变患者抗视网膜抗体滴度及抗视网膜抗体数量与包括视力、主观视力丧失、视野和视网膜电图在内的预后指标之间的可能相关性。
单中心回顾性横断面研究。
纳入在随访期间至少接受两次抗视网膜抗体检测的自身免疫性视网膜病变患者。抗视网膜抗体滴度和数量分为改善、稳定或恶化组。预后指标包括Snellen视力、患者报告的视力丧失、Humphrey视野平均偏差和视网膜电图参数。
纳入了16例自身免疫性视网膜病变患者的31只眼。在95%置信区间，按抗视网膜抗体滴度或数量分组对视力、主观视力丧失、视野和视网膜电图结果进行组间分析，未发现任何显著差异。
抗视网膜抗体滴度或数量的变化与任何视力预后均无关联。自身免疫性视网膜病变诊断并检测到抗视网膜抗体后，可能无需重复进行抗视网膜抗体检测。
