Pucker Andrew D, Lievens Chris, McGwin Gerald, Franklin Quentin X, Logan Amy, Wolfe Gregory S
University of Alabama at Birmingham, Birmingham, AL, USA.
Southern College of Optometry, Memphis, TN, USA.
Clin Optom (Auckl). 2023 Mar 7;15:45-54. doi: 10.2147/OPTO.S398496. eCollection 2023.
To understand the impact of Systane Hydration PF on dryness symptoms and quality of life in digital device users and to determine if participants prefer either the unit-dose or multi-dose dispensing system of Systane Hydration PF.
This 2-week, three visit study recruited regular digital device users. Participants were required to score ≤80 on the Impact of Dry Eye on Everyday Life (IDEEL) Quality of Life (QoL) Work domain and between 13 and 32 on the Ocular Surface Disease Index (OSDI) questionnaire. Participants were randomized to either Systane Hydration PF unit-dose or multi-dose for 1 week and switched to the alternative dosing system for the second week. Participations were evaluated by completing the full IDEEL-QoL module and OSDI questionnaire at each visit. Likert surveys were completed to probe dispensing system preferences.
Thirty participants with a mean ± SD age of 28.6 ± 12.0 years (70% female) were recruited. Participants had significant improvements in all three IDEEL-QoL domains as well as in OSDI scores (all p < 0.0001). Participants had similar preferences for the two dispensing systems, though they were more likely to indicate that they thought that the multi-dose bottle was more environmentally friendly than the unit-dose vials.
Digital device users with dry eye symptoms had meaningful improvements in eye comfort and quality of life scores after being treated with Systane Hydration PF for 2 weeks. Participants did not have a clear dispensing system preference suggesting that the best dispensing system may depend on the patient.
了解思然倍润PF对数字设备使用者干眼症状及生活质量的影响，并确定参与者更喜欢思然倍润PF的单剂量还是多剂量给药系统。
这项为期2周、分三次就诊的研究招募了经常使用数字设备的用户。参与者在日常生活中干眼影响（IDEEL）生活质量（QoL）工作领域的得分需≤80分，在眼表疾病指数（OSDI）问卷上的得分在13至32分之间。参与者被随机分为思然倍润PF单剂量组或多剂量组，为期1周，第二周更换为另一种给药系统。每次就诊时通过完成完整的IDEEL-QoL模块和OSDI问卷对参与者进行评估。完成李克特调查以探究对给药系统的偏好。
招募了30名参与者，平均年龄±标准差为28.6±12.0岁（70%为女性）。参与者在所有三个IDEEL-QoL领域以及OSDI得分均有显著改善（所有p<0.0001）。参与者对两种给药系统的偏好相似，不过他们更有可能表示认为多剂量瓶比单剂量小瓶更环保。
有干眼症状的数字设备使用者在接受思然倍润PF治疗2周后，眼部舒适度和生活质量得分有显著改善。参与者对给药系统没有明确偏好，这表明最佳给药系统可能取决于患者。
