解析聚糖的同分异构异质性：用于无损离子操控的结构中的离子迁移率分离。
Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations.
机构信息
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
出版信息
Chem Commun (Camb). 2018 Oct 25;54(83):11701-11704. doi: 10.1039/c8cc06966b. Epub 2018 Sep 28.
Abstract
To address the challenges associated with glycan analyses, we have implemented a structures for lossless ion manipulations (SLIM) serpentine ultra-long path with extended routing (SUPER) ion mobility-mass spectrometry (i.e. SLIM SUPER IM-MS) platform to achieve much higher resolution of isomeric glycoforms. We have demonstrated the potential of this platform as a future component of the glycomics toolbox.
摘要
为了解决糖链分析所面临的挑战，我们开发了一种结构无损离子操控（SLIM）蛇形超远距离扩展路径（SUPER）离子淌度-质谱（即 SLIM SUPER IM-MS）平台，以实现更高分辨率的异构糖型。我们已经证明了该平台作为糖组学工具包的未来组成部分的潜力。
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