维生素D对2型糖尿病炎症和血脂异常的影响：随机对照试验的系统评价和荟萃分析方案

The Effect of Vitamin D on Inflammation and Dyslipidemia in Type 2 Diabetes Mellitus: Protocol for a Systematic Review and Meta-analysis of Randomized Controlled Trials.

作者信息

MacGirlley Rizqah, Mokgalaboni Kabelo

机构信息

Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Roodepoort, South Africa.

出版信息

JMIR Res Protoc. 2023 Mar 14;12:e42193. doi: 10.2196/42193.

DOI:10.2196/42193

PMID:36917169

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10131654/

Abstract

BACKGROUND

Type 2 diabetes mellitus is a chronic disease that contributes to an increasing global burden on the health system. It has a high chance of leading to macrovascular complications and cardiovascular disease. As an inflammatory condition, it would be essential to target inflammatory pathways when developing therapeutic drugs for type 2 diabetes mellitus.

OBJECTIVE

We aimed to evaluate the effect of vitamin D on markers of inflammation and lipid profile among adult patients with diabetes.

METHODS

A systematic review will seek studies published on Embase, Google Scholar, PubMed, Web of Science, and Science Direct. This planned systematic review and meta-analysis will be limited to randomized controlled trials; moreover, the search will include published studies regarding the effects of vitamin D on pro-inflammatory cytokines and lipid profiles. The review will include studies published from inception until December 30, 2022. The study identification and selection will be based on the eligibility criteria by 2 independent reviewers. Additionally, a meta-analysis will only be performed if more than 2 studies are available and explore the same outcomes, and this will be analyzed using RevMan (version 5.4.1). The quality and risk of bias will be assessed following the Cochrane risk of bias tool and Jadad checklist.

RESULTS

The process for searching literature review has already started, and this is conducted independently by 2 reviewers using a predefined eligibility and "participants, intervention, comparator, and outcome" criteria. This systematic review and meta-analysis will not require any direct involvement of patients and the public; thus, no ethical approval was required.

CONCLUSIONS

The findings obtained from the proposed study will be presented in scientific seminars, journal clubs, and conferences and published in peer-reviewed journals.

TRIAL REGISTRATION

International Platform of Registered Systematic Review and Meta-analysis Protocols INPLASY202260022; https://inplasy.com/?s=INPLASY202260022.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/42193.

摘要

背景

2型糖尿病是一种慢性病，给全球卫生系统带来日益沉重的负担。它极易引发大血管并发症和心血管疾病。作为一种炎症性疾病，在研发2型糖尿病治疗药物时，针对炎症途径至关重要。

目的

我们旨在评估维生素D对成年糖尿病患者炎症标志物和血脂谱的影响。

方法

将在Embase、谷歌学术、PubMed、科学网和科学直投上检索已发表的研究，进行系统评价。这项计划中的系统评价和荟萃分析将限于随机对照试验；此外，检索将包括关于维生素D对促炎细胞因子和血脂谱影响的已发表研究。该评价将纳入从开始到2022年12月30日发表的研究。研究的识别和选择将基于两名独立评审员的纳入标准。此外，只有在有两项以上研究且探讨相同结果时才进行荟萃分析，并使用RevMan（5.4.1版）进行分析。将按照Cochrane偏倚风险工具和Jadad清单评估质量和偏倚风险。