Marinova P, Nikolova S, Tsoneva S
Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria.
Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria.
Russ J Gen Chem. 2023;93(1):161-165. doi: 10.1134/S1070363223010218. Epub 2023 Mar 9.
This paper represents a convenient method for the synthesis of -[1-(2-acetyl-4,5-dimethoxyphenyl)propan-2-yl]benzamide and its Cu(II) complex. In silico analysis predicted spasmolytic activity for the compound. Based on the in silico calculations, the importance of the predicted ketoamide, and our previous experiments, we synthesized the ketoamide via -acylation of -[1-(3,4-dimethoxyphenyl)propan-2-yl]benzamide with acetic anhydride in polyphosphoric acid. We applied the title ketoamide in reaction with Cu(II) varying the solvents. We found that the reaction leads to the formation of a coordination compound when the ligand dissolved in DMSO reacts with a water solution of CuCl in an alkaline environment in a molar ratio M : L : OH = 1 : 2 : 2. The structures of the new compounds are discussed based on their melting points, IR, H, C NMR and Raman spectral data.
本文介绍了一种合成 -[1-(2-乙酰基-4,5-二甲氧基苯基)丙-2-基]苯甲酰胺及其铜(II)配合物的简便方法。计算机模拟分析预测该化合物具有解痉活性。基于计算机模拟计算、预测的酮酰胺的重要性以及我们之前的实验，我们通过在多磷酸中用乙酸酐对 -[1-(3,4-二甲氧基苯基)丙-2-基]苯甲酰胺进行 - 酰化反应合成了酮酰胺。我们将标题酮酰胺用于与不同溶剂中的铜(II)反应。我们发现，当溶解在二甲亚砜中的配体在碱性环境中与氯化铜水溶液以摩尔比M : L : OH = 1 : 2 : 2反应时，该反应会生成一种配位化合物。基于新化合物的熔点、红外光谱、氢谱、碳谱和拉曼光谱数据对其结构进行了讨论。
